Live Biotherapeutics Drug Discovery Services for Anxiety and Depression

Probiotics are living microbes that boost the healthy life of the host’s system to reduce the side effects of gastrointestinal tract disease symptoms. Researchers now believe that the complex bidirectional communication that occurs between the brain and gut microbiota (GM) could be a new way forward in determining therapies for mental illness. Creative Biolabs is committed to providing overall solutions for next-generation probiotics (NGPs) drug research and development. Our team has rich experience in probiotics discovery services and we provide accurate and effective solutions for researchers around the world.

Introduction of Anxiety and Depression

Around 15%-20% of people will experience mental health disorders such as a depressive episode or anxiety disorder in their lifetime. Anxiety and depression are ranked in the top 10 causes of the global burden of disease. Unfortunately, our understanding of these disorders and the ability to effectively treat them are poor. The high impacts on individual quality of life, as well as on the public health system, determine that preventing and treating anxiety and depression is a global priority.

Treatment of Anxiety and Depression

  • Beneficial Effects of Probiotics Treatment

A study using different species of probiotics showed beneficial effects, such as reducing the levels of anger-hostility, depression, and somatization in healthy human volunteers. The consumption of yogurt containing Lactobacillus casei (L. casei) Shirota improved the mood of healthy individuals. Consumption of probiotic supplement significantly decreased the Beck Depression Inventory (BDI) scores and improved the mood as well as overall symptoms in patients diagnosed with depression.

The gut-brain axis pathway. Fig.1 The gut-brain axis pathway. (Clapp, 2017)

  • Effects of Probiotics on Behavior

The study reported that a group of forty healthy young adults showed a significant reduction in overall cognitive reactivity to depression as well as ruminative and aggressive thoughts after consuming a probiotic mixture for 4 weeks.

  • Probiotics with Anxiety and Depressive Symptoms

The consumption of a probiotic mixture along with the immunomodulator Del-Immune V reduced the severity of autism in 33 children. Human and animal studies of probiotics show similar reductions in anxiety and depressive symptoms. Human patients suffering from chronic stress were given a three-week probiotic treatment containing Bifidobacteria species. Subjects in the bottom third of the elated/depressed scale demonstrated the most improvement with treatment. In a 30-day study, healthy volunteers with no previous depressive symptoms were given either probiotics or antidepressants. Those given probiotics showed reduced cortisol levels and improved self-reported psychological effects to a similar degree as participants administered Diazepam, a commonly used anti-anxiety medication. Analogous studies found that probiotic therapy reduced depressive symptoms and improved HPA-axis functionality as well as Citalopram and Diazepam.

Why Probiotics Are Priority?

Comparing probiotics to the antidepressant escitalopram in mice, the probiotics were discovered to have similar effects. They were equally successful in anxiety reduction and were more effective than the escitalopram in maintaining healthy metabolism and body weight. What’s more, probiotics possess higher safety than traditional medicines.

Creative Biolabs has extensive experience in NGPs development and currently can provide strain technical services, drug discovery services, and product development services for the treatment of mental disease. The process of knowledge exchange is invaluable, and we will use our expertise to boost your business and research. If you are interested in our services, please contact us for more information.


  1. Clapp, M.; et al. Gut microbiota's effect on mental health: the gut-brain axis. Clin Pract. 2017, 15: 7(4).

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