Live Biotherapeutics Drug Discovery Services for Autism Spectrum Disorder (ASD)

With the growing research on probiotics and the integral part, they play in the health of the gastric intestinal (GI) tract and the whole body, their inclusions as an integrative treatment may be of great use for children with ASD. Creative Biolabs provides a series of next-generation probiotics (NGPs) discovery and analysis services characterized by quality, predictability, delivery, and customization. Our employees have the operational courage and scientific background that you need for your success.

Introduction of ASD

ASD is a neurodevelopmental behavioral disorder that has an important impact on children's development and society because children usually have some symptoms such as communication disorders, narrow interests, and stereotyped behavior. It is reported that the human brain and behavior and mental health can be affected by intestinal microbiota through the gut-brain axis.

Potential relationships between the microbiota and ASD. Fig.1 Potential relationships between the microbiota and ASD. (Qinrui, 2017)

Treatment of ASD

At present, there is no good treatment for ASD. Children with ASD and GI symptoms, compared to those without GI symptoms, display significantly higher measures of irritability, anxiety, and social withdrawal. More and more evidence showed that the regulation of gut microbiota is a potential treatment for ASD children.

  • One ASD boy with a severe cognitive disability was treated with VSL#3 (a multi-strain mixture of 10 probiotics) for 4 weeks. The treatment improved the autistic core symptoms.
  • Patients with chronic fatigue syndrome (almost all chronic fatigue syndrome patients report neuropsychological disturbances) received 24 billion colony-forming units of Lactobacillus casei for 2 months, and a significant decrease in anxiety symptoms and a significant increase in Bifidobacteria and Lactobacillus were observed.
  • Administration of Bifidobacterium infantis in a rat model of depression showed effects on immune, neuroendocrine, and central monoaminergic activity.
  • Probiotics are a benefit for anxiety people and healthy people. Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 were administered to healthy women for 30 days, and then anxiety, depression, and 24h free cortisol levels in the urine were then assessed. The results found that probiotics alleviated psychological distress.
  • A probiotic drink containing Lactobacillus casei has also revealed positive effects on mood and cognition in volunteers.

Creative Biolabs focuses on the development and validation of complex analytical methods for NGPs. Our goal is to provide the optimal test mix and specialized services to successfully meet the requirements of your NGPs' trial in the most effective and cost-efficient manner. We have many years' experience and our laboratory is equipped with the very latest instrumentation, so we can offer you the products with the highest quality, accuracy, and precision. If you are interested in our services, please feel free to contact us.

Reference

  1. Qinrui, Li.; et al. The Gut Microbiota and Autism Spectrum Disorders. Frontiers in Cellular Neuroence. 2017, 110-120.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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