Creative Biolabs isolates L. jensenii from healthy-donor samples and builds a high-performance seed bank by ranking isolates for hydrogen peroxide output, D-lactic-acid–linked acidification kinetics, and broad antagonism against relevant challenge organisms. Screening leverages validated quantitation approaches to avoid false positives across media and oxygen conditions.
To substantiate L. jensenii protective ecology, we quantify hydrogen peroxide and lactate production kinetics, then connect them to competitive exclusion and inhibition metrics against representative vaginal pathogens. Mechanistic packages can include adhesion-interference evidence and secreted factor profiling to support claims with traceable, testable MoA logic.
Our antifungal module evaluates how L. jensenii and its metabolites suppress Candida albicans growth, hyphal transition, and biofilm behaviors under vaginally relevant conditions. Readouts focus on strain-ranked activity of live cells vs. cell-free supernatants, enabling rational selection of candidates best suited for women’s health formulation concepts.
Because colonization is the gatekeeper of function, Creative Biolabs uses vaginal epithelial cell models to quantify L. jensenii adhesion, persistence, and barrier-associated responses. We also support inflammation-aware profiling where appropriate, helping sponsors demonstrate that L. jensenii can coexist with host cells while maintaining stable functional output.
L. jensenii can be demanding in oxygen control, pH stability, and nutrient balance. We optimize media (carbon/nitrogen ratios, micronutrients) and process parameters to reach high-density growth while preserving target attributes—especially hydrogen peroxide production capacity and viability—across scale-up steps and production lots.
Creative Biolabs designs L. jensenii formulations aligned with urogenital use-cases, including vaginal dosage concepts (e.g., suppository, gel-compatible, or lyophilized presentations) in addition to oral formats. We optimize protectant systems, reconstitution behavior, and release profiles to reduce processing damage and protect strain performance.
Shelf stability is often the commercialization bottleneck for L. jensenii. We run accelerated and long-term stability studies with survival tracking under multiple temperature/humidity and packaging conditions, linking viability retention to critical quality attributes so teams can set realistic storage claims and release specifications early.
Safety files for L. jensenii require more than “no issues observed.” We assess antibiotic susceptibility patterns, screen for transferable resistance risk, evaluate hemolysis, and review genomic/phenotypic virulence indicators. The outcome is a regulator-aligned evidence package suitable for research-driven product development decisions.
