Lactobacillus jensenii as Next Generation Probiotics

Lactobacillus jensenii (L. jensenii) is a class of normal vaginal microflora which utilizes glycogen in the vaginal epithelium to produce acids maintaining the acidic conditions of the vagina. This microorganism plays an essential role in protecting the vagina from harmful pathogens. L. jensenii has been proposed to develop a promising probiotic to treat vaginal diseases. Creative Biolabs is an outstanding service provider who is skilled in offering the best next-generation probiotics development services for global customers based on a variety of technologies.

Introduction of L. jensenii

L. jensenii, belonging to the genus Lactobacillus, is a type of rod-shaped, anaerobic gram-positive microorganisms. It is a part of the natural vaginal microflora colonizing biofilms of the vaginal mucosa in healthy females, accounting for 23% of all vaginal colonies (following L. crispatus-32%), making it the second most common lactobacillus in the lower genital tract of women. The role of L. jensenii is to produce acids in the vagina through anaerobic metabolism of glycogen. The glycogen is deposited in the vaginal epithelium when there has a high concentration of estrogen, specifically during the period of menstruation. The vaginal microflora and surrounding epithelial cells can use the glycogen to produce acetic and lactic acid, keeping the vaginal pH at about 4. The strong acidic vaginal environment contributes to inhibiting the growth of harmful bacterial, protecting the vagina from harmful pathogens. Besides, L. jensenii can compete with harmful bacteria for nutrients and produce antimicrobial compounds, thereby inhibiting the growth of pathogens.

Lactobacillus spp. near a squamous epithelial cell. Fig.1 Lactobacillus spp. near a squamous epithelial cell.

L. jensenii Probiotics for Treatment of Urinary Tract Disorders

The vaginal environment is a fragile ecosystem that functions well at a fairly acidic pH of 3.8-4.5. If the pH value of the vagina is kept at a high level for a long time, the risk of vaginal imbalance is higher. Vaginal imbalance may increase the occurrence of vaginal diseases such as vaginitis. To treat vaginosis, some medications such as antihistamines or antibiotics may be recommended. However, these medications can alter the vaginal pH and, in the case of antibiotics, can kill off all of the bacteria inside the vagina, both beneficial and harmful, leaving a disordered vaginal ecosystem.

Recently, L. jensenii, a type of normal vaginal microflora, is expected to be developed as next-generation probiotics for the treatment of genital related diseases such as gonorrhea and HIV infection. L. jensenii engineered to express functional two-domain CD4 has been shown to block the transmission of HIV. L. jensenii isolated from the female genital tract can inhibit the growth of Neisseria gonorrhoeae that is a leading cause of gonorrhea at low pH and neutral pH.

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With years of experience in the development of next-generation probiotics, we are very confident in offering a full range of next-generation probiotics development services for our customers around the world, including identification and isolation of next-generation probiotics, safety test for probiotics products, host-microbe interaction test, and cGMP manufacturing of probiotics products. Our services will advance the development of next-generation probiotics.


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If you are interested in our services, please hesitate to contact us for more details. We will be the most powerful and reliable partner in the field of next-generation probiotics development.

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