Blautia wexlerae
Microbiome CRO Services

Creative Biolabs supports microbiome innovators in pharma, food, and biotech with end-to-end CRO solutions—strict anaerobic cultivation, functional readouts, scalable fermentation, and stabilization—purpose-built to translate Blautia wexlerae insights into robust, decision-ready data for development programs.

Preferred by Microbiome Innovators

Chosen by teams that value rigorous anaerobic workflows, transparent data packages, and reproducible, publication-standard methods from discovery through scale-up.

Fig. 2. Akkermansia muciniphila microbiome CRO services partner-1 (Creative Biolabs Authorized)

Fig. 3. Akkermansia muciniphila microbiome CRO services partner-2 (Creative Biolabs Authorized)

Fig. 4. Akkermansia muciniphila microbiome CRO services partner-3 (Creative Biolabs Authorized)

Fig. 5. Akkermansia muciniphila microbiome CRO services partner-4 (Creative Biolabs Authorized)

Fig. 6. Akkermansia muciniphila microbiome CRO services partner-5 (Creative Biolabs Authorized)

Why Choose a Dedicated B. wexlerae Service?

Human and animal studies highlight B. wexlerae as an acetate-rich commensal associated with favorable metabolic profiles; in controlled experiments, administration remodeled microbial metabolism and improved obesity- and glycemia-related readouts while shifting SCFAs (succinate, lactate, acetate). These findings make B. wexlerae a high-priority research strain.

Beyond metabolism, emerging evidence links Blautia abundance to mucus integrity and barrier function—core endpoints for gut health models—further motivating standardized assays spanning epithelial adhesion, TEER, and mucin dynamics.

B. wexlerae microbiome services (Creative Biolabs Original)

What We Offer for B. wexlerae

Microbial Isolation and Screening Services

We perform strict anaerobic isolation and clonal purification of B. wexlerae, combining selective media and high-throughput colony picking to rapidly recover genetically clean, phenotypically stable working strains. Each isolate undergoes standardized growth-kinetics checks, purity verification, and cryobank registration for traceable, future-proof studies.

Microbial Identification Services

Identity is confirmed by dual pipelines—16S rRNA/WGS plus MALDI-TOF—to distinguish B. wexlerae from closely related Blautia species/strains. Deliverables include phylogenetic placement, genome quality metrics, and functional gene annotations relevant to carbohydrate use, SCFA biogenesis, and stress responses.

Specific Primers and Probes Design

We design B. wexlerae-specific qPCR/ddPCR primers and hydrolysis probes for high-specificity detection in complex matrices (stool, mixed consortia, bioreactor broths). Assays are multiplex-ready, sensitivity-verified, and delivered with dynamic range, efficiency, and limit-of-detection documentation.

Carbohydrate Fermentative Profiles

We map B. wexlerae carbon-source utilization and SCFA output (acetate, succinate, lactate; optional butyrate cross-feeding analysis) using GC/LC quantification, gas evolution, and pH kinetics. Outputs identify optimal substrates and metabolic fingerprints for media design or product development.

Functional and MoA Screening

We quantify barrier and immune-relevant mechanisms for B. wexlerae: tight-junction markers (ZO-1/occludin), mucin metrics, TLR/NF-κB reporter responses, and bile-salt hydrolase/polysaccharide-pathway readouts. Optional metabolomics tracks amino-acid-derived mediators (e.g., acetylcholine, SAM, L-ornithine) implicated in host interactions.

Host-Microbe Interaction Tests

We test B. wexlerae with Caco-2/HT29-MTX co-cultures, mucus-enriched inserts, and 3D gut-on-chip systems to assess adhesion, barrier permeability (TEER), cytokine panels, and co-metabolites. Designs can include immune co-culture (macrophages, DCs) to profile cross-talk at the epithelial interface.

Microbial Fermentation Services

Anaerobic bioreactors (batch/fed-batch/continuous) are optimized for B. wexlerae growth and metabolite productivity via pH/redox control, nutrient feeds, agitation, and gas strategies. We deliver scalable parameters, in-process analytics, and harvest methods supporting live-cell and cell-free material supply.

Microbial Stabilization Services

For oxygen-sensitive B. wexlerae, we screen protectants (e.g., glycerol, trehalose), define lyophilization or spray-drying windows, and validate residual-O₂ packaging. Stability protocols verify viability/functional retention during transportation and storage, enabling consistent multi-site testing.

How B. wexlerae Project Runs

Scope & Endpoints

Align on objectives, matrices, and decision criteria (e.g., SCFA targets, TEER deltas, cytokine signatures).

Strain & Assays

Select B. wexlerae strains, design identity/quant assays, and predefine functional readouts and success thresholds.

Anaerobic Culture & QC

Manufacture working banks under strict anaerobiosis; perform identity, purity, and viability checks with batch records.

Mechanism Readouts

Execute barrier, immune, and metabolic assays; integrate GC/LC-SCFA, reporters, and imaging as required.

Scale-Up & Stabilization

Optimize bioreactors and dry-down/packaging for target performance and logistics.

Analysis & Reporting

Deliver GLP-style data packages, statistical analyses, and next-step recommendations for your program.

Advantages of Our B. wexlerae Services

Anaerobe-First Infrastructure

Dedicated isolators, anoxic handling, and redox-controlled bioreactors for fastidious commensals.

Mechanism-Rich Readouts

Orthogonal barrier, immune, and metabolite endpoints to de-risk interpretation.

Design for Scale

Early attention to media, feeding, and stabilization eases the transition from bench to pilot.

Traceable Quality

Bank management, batch records, and lot-release analytics keep data audit-ready.

Matrix Versatility

From stool and gut models to bioreactors and formulated lots, one vendor spans the workflow.

Collaborative Science

Senior scientists co-design studies and translate findings into actionable next experiments.

Research Applications of B. wexlerae

Metabolic Health and Glycemic Control

Human cohort data link lower B. wexlerae abundance with obesity and type-2 diabetes. In high-fat diet mice, oral B. wexlerae reduced weight gain and improved insulin sensitivity through SCFA-driven metabolic remodeling.

Inflammation Modulation

B. wexlerae and its metabolites display anti-inflammatory activity, reducing pro-inflammatory markers and adipose macrophage accumulation. Research models motivate assaying cytokines, NF-κB signaling, and barrier function to quantify host–microbe immunomodulatory interactions.

Male Reproductive Function in Obesity

In obese, infertile men, reduced B. wexlerae levels are reported. In obese mice, administration improved fertility indices, decreased oxidative stress, and suppressed NLRP3 inflammasome activation, suggesting an axis for reproductive-metabolic research.

Neurodevelopment and Cognition

Emerging studies associate B. wexlerae with higher cognitive scores in children. Research programs can interrogate metabolite–brain pathways—SCFAs, amino-acid derivatives, vagal signaling—using longitudinal cohorts, neurocognitive batteries, and microbe-metabolite profiling for hypothesis-driven validation.

Gastrointestinal Barrier and Chemotoxicity Readouts

Through acetate, lactate, and succinate production, B. wexlerae supports mucosal integrity and barrier function. Preclinical evidence indicates potential to attenuate gastrointestinal toxicity from 5-fluorouracil, informing epithelial models and inflammation-damage readouts.

Functional and Medical Food Prototyping

Given favorable metabolic and barrier signals, B. wexlerae is being explored for functional foods and LBP concepts. CRO programs profile identity, safety, and mechanisms to de-risk prototypes and inform development dossiers.

Fig. 8 Sample submission form (Creative Biolabs Original)

Partner with our experts to advance your B. wexlerae research with clarity and precision.

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B. wexlerae Related Products

Find our Blautia wexlera product:

Product Name	Catalog No.	Target	Product Overview	Size	Price
*Blautia wexlerae*	LBSX-0522-GF94	Blautia	Blautia wexlerae was isolated from human faeces.	—	—

FAQs

We pair 16S/WGS with MALDI-TOF and curated reference genomes. Phylogenetics narrows species calls; genome QA, ANI/GTDB metrics, and marker-gene panels verify B. wexlerae status before bank release and downstream assays.

For barrier: TEER shifts, tight-junction staining, and mucin metrics. For immune: TLR/NF-κB reporters and cytokine panels. For metabolism: GC/LC-SCFA and targeted metabolomics (acetylcholine, SAM, L-ornithine) informed by literature.

We screen cryo/excipient systems (e.g., trehalose) and define lyophilization or spray-dry windows under low-oxygen handling. Residual-O₂ packaging and cold-chain validation preserve viability and function across transit durations.

Yes. We translate bench media into redox-controlled bioreactors with feed strategies to maintain growth and SCFA profiles. In-process analytics and release criteria ensure phenotype and performance remain consistent lot-to-lot.

Other Resources

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References

Hosomi, Koji, et al. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota." Nature communications 13.1 (2022): 4477. https://doi.org/10.1038/s41467-022-32015-7
Zhong, Yucheng, et al. "Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility." Medical Microbiology and Immunology 213.1 (2024): 11. https://doi.org/10.1007/s00430-024-00796-x
Holmberg, Sandra M., et al. "The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids." Nature Communications 15.1 (2024): 3502. https://doi.org/10.1038/s41467-024-47594-w
Liu, Xuemei, et al. "Blautia—a new functional genus with potential probiotic properties?." Gut microbes 13.1 (2021): 1875796. https://doi.org/10.1080/19490976.2021.1875796

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Blautia wexlerae Microbiome CRO Services