Bacteroides thetaiotaomicron as Next Generation Probiotics
Background B. thetaiotaomicron and Diseases Services Products FAQs Resources
Bacteroides thetaiotaomicron (B. thetaiotaomicron) is a prevalent species within the human gut microbiota. It has previously been shown that B. thetaiotaomicron has anti-inflammatory properties and can increase mucosal barrier function and limit pathogen invasion. Based on the existing theory, coupled with data from our in-house in vitro screening platform, Creative Biolabs assesses the activity of various B. thetaiotaomicron strains and offers live biotherapeutic products as well as drug discovery services for global clients.
B. thetaiotaomicron Introduction
B. thetaiotaomicron, a gram-negative obligate anaerobe, is a species of bacterium which belongs to the genus Bacteroides. It is one of the most common bacteria found in human gut flora and is also an opportunistic pathogen. Its genome contains numerous genes specialized in the digestion of polysaccharides. B. thetaiotaomicron is capable of metabolizing different kinds of polysaccharides. Its complement of enzymes for hydrolysis of glycosidic bonds is among the largest known in prokaryotes, and it is thought to be capable of hydrolyzing most glycosidic bonds in biological polysaccharides. Besides, published studies have revealed that B. thetaiotaomicron modulate the expression of a large number of genes implicated in different aspect of host physiology.
B. thetaiotaomicron and Disease
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Diseases
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Functions of B. thetaiotaomicron
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Inflammatory Bowel Disease (IBD)
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Alterations in the gut microbiota are strongly associated with the development of IBD, particularly with Crohn's disease (CD). IBD is characterized by a reduced abundance of commensal anaerobic bacteria including members of the Bacteroides genus. Studies revealed that B. thetaiotaomicron displays strong efficacy in preclinical models of IBD and protects against weight loss, histopathological changes in the colon, and inflammatory markers. Together, these data indicate that the live strain or its products could be a novel alternative to current treatment options for CD.
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Ulcerative Colitis (UC)
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Scientists assessed the activity of B. thetaiotaomicron type strain in well-characterized rodent models of colitis. The results indicated that BT was efficacious in reducing the primary disease readouts in dextran sulphate sodium (DSS) mouse and rat models of colitis and interleukin-10 knockout (IL10KO) mice. Thus, treatment with BT could potentially reverse inflammatory responses and ultimately reduce symptoms of colitis.
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Rheumatoid Arthritis (RA)
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Recent accumulating evidence supports that B. thetaiotaomicron is thought to be an environmental agent affecting the development and pathogenesis of RA. Evidence suggests that some enteric microorganisms can reduce pro-inflammatory cytokines level under the prerequisite not affecting regulating cell cytokines level, thus plays anti-inflammatory action, alleviates RA symptoms. Besides, it is demonstrated that the presence of B. thetaiotaomicron can provide different signals for several aspects of intestinal development, including mucosal barrier fortification, angiogenesis, xenobiotic metabolism, and postnatal intestinal maturation.
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NGP Discovery Services at Creative Biolabs
Creative Biolabs provides a comprehensive suite of B. thetaiotaomicron analytical development and qualification services. Customized B. thetaiotaomicron-based therapeutic discovery services will be available according to your projects.
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FAQs
Are there any specific applications of B. thetaiotaomicron in research?
B. thetaiotaomicron is utilized in research focused on understanding the human microbiome's role in health and disease. Its applications include studies on gut barrier integrity, host-microbe interactions, immune system modulation, and the development of microbial-derived therapies. Its versatile metabolic capabilities also make it a model organism for exploring microbial ecology and evolution.
How can B. thetaiotaomicron probiotic discovery services benefit researchers?
The discovery services dedicated to B. thetaiotaomicron are designed to empower researchers with advanced tools and methodologies for isolating, characterizing, and utilizing this bacterium for various scientific endeavors. These services facilitate a deeper understanding of the organism's genomic, proteomic, and metabolic profiles, enabling the development of targeted probiotic formulations.
Are your B. thetaiotaomicron products and services available for clinical use?
Currently, Creative Biolabs’ B. thetaiotaomicron products and services are exclusively available for research purposes and are not intended for diagnostic or therapeutic use. These offerings are tailored to support the scientific community in understanding the bacterium's role within the microbiome and its potential health benefits.
Resources
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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