Lactobacillus gasseri as Next Generation Probiotics
In recent years, a probiotic called Lactobacillus gasseri (L. gasseri) has received extensive attention. It is believed that this kind of bacteria can help the human body by inhibiting harmful bacteria, which in turn can enhance immune function and help digestion.
Introduction of L. gasseri
Like other members of the Lactobacillus genus, L. gasseri is an anaerobic Gram-positive bacterium, belonging to the category of lactic acid bacteria. It is also a rod-shaped and non-sporogenic type. Its genome is circular, contains 1.89 Mb, and has a GC content of 35.3%. Besides, 1755 different proteins and 98 different RNAs were identified in L. gasseri. Like other lactic acid bacteria, L. gasseri is acid-resistant, cannot synthesize porphyrin, and has strict fermentation metabolism with lactic acid as the main metabolic end product. Because of its main fermentation function, it usually exists in the gastrointestinal (GI) tract of humans and animals. At the same time, it is also a normal resident of the lower reproductive tract of healthy women.
Fig.1 Cultivable levels of L. gasseri throughout the human mucosa. (Selle, 2013)
Benefit of L. gasseri in Diseases
L. gasseri has shown good survival in many organs of the human body, including the GI tract, and is related to the activities and functions of a variety of probiotics, including reducing fecal mutagenic enzymes, adhering to intestinal tissues, stimulating macrophages, and producing bacteriocin.
Many clinical trials and animal-based studies indicate that L. gasseri may help reduce belly fat and support weight loss. One of them is a study published in the British Journal of Nutrition in 2013, in which 210 obese adults were provided milk rich in L. gasseri or placebo milk. After 12 weeks, compared with the placebo group, the abdominal fat of the Lactobacillus group decreased by 8.5.
Lactobacillus is a probiotic that is believed to relieve inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Studies have shown that L. gasseri plays an anti-inflammatory effect in the colon, which is particularly beneficial to alleviating the symptoms of IBS and ulcerative colitis.
A previous study showed that when administered via suppositories, L. gasseri was more effective in reducing the recurrence of bacterial vaginosis than when administered via the oral cavity. Besides, it can also help relieve menstrual pain in women with endometriosis.
Drug Discovery Service of L. gasseri
In the previous project experience, we have evaluated the probiotic activity of L. gasseri based on the availability of genome sequence and species-specific adaptability to human mucosa. In humans, L. gasseri obtains various health benefits through its antibacterial activity, bacteriocin production, and immune regulation of the innate and adaptive systems.
Creative Biolabs has enough confidence and successful experience in probiotic drug development to provide the best service to our customers all over the world. We encourage future probiotic formulations to include sources of isolation, taking into account genetic and phenotypic characteristics, for use at different body parts. Also, we will carry out a series of safety, effectiveness, stability analysis in the process of drug development to ensure the quality and safety of probiotics. If you are interested in our services and products, please feel free to contact us for more information.
Reference
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Selle, K., Klaenhammer, T. R. Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. FEMS microbiology reviews. 2013, 37(6): 915-935.
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