Creative Biolabs offers targeted isolation of L. gasseri from defined niches (e.g., human milk, gut, or vaginal samples) and screens candidates for acid/bile tolerance, adhesion-associated phenotypes, and stress resilience. The goal is to shortlist high-activity L. gasseri strains with strong colonization potential and development readiness.
We validate L. gasseri functions aligned to your indication concept—such as lipid-metabolism–linked readouts, vaginal ecosystem support signals, and inflammation-associated biomarker panels—then connect phenotypes to mechanistic clues (metabolites, pathway markers, and immunologic signatures). This enables a defensible MoA story for L. gasseri in R&D-grade terms.
Using in vitro host models (e.g., Caco-2 and vaginal epithelial platforms), Creative Biolabs quantifies L. gasseri adhesion, barrier-relevant responses, and immune signaling shifts. These assays help determine whether your L. gasseri strain can meaningfully engage host surfaces and trigger measurable, reproducible cellular responses under controlled conditions.
For women’s health and broader bioprotective concepts, we profile L. gasseri antimicrobial outputs—including organic acids and bacteriocin activity (e.g., gassericin-associated effects)—against representative challenge organisms in standardized inhibition formats. Classical studies describing gassericins support why peptide-level characterization can be a differentiator for L. gasseri candidates.
Because L. gasseri performance can be constrained by anaerobic preferences and slow growth kinetics, we optimize media C/N balance, redox conditions, feeding strategy, and process parameters to improve biomass and consistency. The outcome is an industry-aligned fermentation protocol for L. gasseri that supports downstream formulation and lot-to-lot comparability.
Creative Biolabs designs freeze-drying protectant systems and microencapsulation options tailored to L. gasseri sensitivity to processing stress. We focus on maintaining viable counts and functional integrity through drying, storage, and rehydration—so L. gasseri performance in assays is not lost during real manufacturing-like handling.
We run accelerated aging and long-term stability studies to quantify how temperature, humidity, oxygen exposure, and packaging choices affect L. gasseri viability and key functional attributes. Data are delivered as shelf-life–relevant curves and decision-ready specifications that support formulation selection and packaging strategy.
Creative Biolabs provides compliance-oriented safety evaluation for L. gasseri, including antibiotic resistance profiling, hemolysis screening, and in vivo acute tolerance study options where appropriate. The goal is a documentation package aligned with global expectations (e.g., GRAS/QPS-style thinking) for research and product development decision-making.
