Creative Biolabs performs selective isolation and screening of C. leptum from feces, gut contents, or bioreactor communities under strictly anaerobic conditions. We enrich, purify, and phenotype C. leptum candidates for butyrate output, carbohydrate utilization, immunomodulatory features, and suitability for downstream microbiome or LBP studies.
Accurate taxonomic and functional identification of C. leptum is essential for reproducible microbiome research. We combine 16S rRNA cluster-specific assays, targeted qPCR, and whole-genome sequencing to confirm C. leptum identity, resolve close relatives within cluster IV, and link genomic signatures to strain performance and safety attributes.
Because C. leptum is highly oxygen-sensitive, long-term stability is a major technical hurdle. Creative Biolabs develops custom stabilization strategies for C. leptum, including cryopreservation, lyophilization, carrier matrices, and packaging concepts that preserve viability, genetic integrity, and functional traits across storage, shipment, and formulation stress testing.
Our functional and mechanism-of-action (MoA) screening for C. leptum integrates in vitro immunology assays, epithelial barrier models, and co-culture systems. We profile Treg induction, cytokine modulation, barrier reinforcement, and cross-talk with other gut microbes to define mechanistic signatures relevant to allergy, IBD, metabolic, and neuroimmune research.
Creative Biolabs characterizes carbohydrate fermentative profiles of C. leptum using high-throughput anaerobic fermentation and metabolomics. We quantify SCFAs (including butyrate), lactate, gases, and secondary metabolites across fibers, resistant starches, and bespoke prebiotic substrates, supporting precision nutrition design and rational prebiotic–probiotic pairing strategies.
Our host–microbe interaction tests for C. leptum employ gut epithelial monolayers, mucus-producing co-cultures, and immune cell assays. We assess barrier integrity, tight-junction modulation, innate and adaptive immune responses, and gut–lung axis signaling to map how C. leptum shapes host physiology in controlled systems.
Creative Biolabs offers scalable anaerobic fermentation of C. leptum, from small-volume discovery batches to lab-scale production for animal studies. We optimize media, redox potential, and process parameters to maximize viable cell yields, metabolite profiles, and consistency across runs for downstream formulation or consortium assembly.
For groups exploring C. leptum as a next-generation probiotic candidate, we provide engineering and optimization services. These include strain selection, stress-tolerance enhancement, consortia design, genome-based safety annotation, and formulation compatibility testing to support rational development of C. leptum–containing microbiome interventions under research settings.
