Clostridium leptum as Next Generation Probiotics

Clostridium leptum (C. leptum) is one of the three dominant bacteria in the human gut. It has been linked to a variety of diseases. Creative Biolabs is an outstanding, independent USA company offering quality live biotherapeutic product (LBP) related products and first-class customer service to leading pharma, biotech, contract research organizations and universities worldwide. We have deep experience in strain development.

Introduction of C. leptum

The C. leptum group of bacteria is one of the dominant groups of fecal bacteria in adult humans, constituting 16-25% of the fecal microbiota. Among human faecal bacteria, many members of the C. leptum subgroup are fibrolytic and butyrate producing microorganisms thereby contributing to processes important to colonic health. C. leptum subgroup represented 22% of the total faecal bacteria and co dominated with members of Clostridium coccoides group. Members of the C. leptum subgroup are thought to be highly oxygen-sensitive anaerobic bacteria. In adult mice, it maintains the intestinal microecological balance, promotes immune maturation, and increases Treg numbers to alleviate airway inflammation.

C. leptum for Disease Treatment

Oral feeding with <em>C. leptum</em> reduces allergic airway inflammation in mice. Fig.1 Oral feeding with C. leptum reduces allergic airway inflammation in mice. (Li, 2012)

Adult BABL/C mice were injected with ovalbumin to induce asthma, followed by oral C. leptum or vehicle for 2 weeks. The results showed that oral feeding with C. leptum increased the percentage and the total number of regulatory T cells (Tregs) in the spleens and mediastinal lymph nodes at 14 days after inoculation and attenuated allergen-induced airway hyperresponsiveness and inflammation by inhibiting inflammatory cytokine production but enhancing interleukin 10 and transforming growth factor 1 production in the lungs. C. leptum can attenuate induced allergic airway inflammation in adult mice. Therefore, the findings may provide a new basis for the design of novel probiotic therapies for the treatment of asthma.

Alterations in the fecal bacterial flora occur in IBD. The diversity study of C. leptum group in IBD patients, provides important information regarding the colonic microbiota in IBD. Studies have shown that in ulcerative colitis (UC) and Crohn’s disease (CD), both the absolute number of C. leptum groups and the species per individual are reduced. C. leptum (Clostridium clusters IV) appears to be a plausible factor associated with UC. This loss of diversity may affect gut health, even if it's not the main phenomenon that causes intestinal inflammation. Ingestion of prebiotic substrates such as inulin can increase bifidobacteria and F. prausnitzii in the human gut, which may be a possible intervention to treat patients with IBD. Treatment of butyric-producing bacteria such as C. leptum group in IBD patients may be an alternative treatment option for these patients.

Role of the gut microbiota in the pathogenesis of UC. Fig.2 Role of the gut microbiota in the pathogenesis of UC. (Zhang, 2017)

What Services Can We Provide for C. leptum at Creative Biolabs?

C. leptum Related Products at Creative Biolabs

  • Strain Products

We supply a variety of C. leptum strains of different preservation numbers as below. If you need other strains, please contact us.

CAT Product Name Product Overview
LBST-064FG Clostridium leptum; VPI T7-24-1 Clostridium leptum VPI T7-24-1 is an anaerobe, mesophilic bacterium that was isolated from human faeces. It is a bacterium species in the genus Clostridium.
  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs offers technical expertise and experience to provide traceable, customizable LBP development solutions. We have been selected by our large pharmaceutical and biotechnology clients for our flexibility, professionalism, high-cost performance, and fast turnaround time. If you are interested in our C. leptum related products and services, please contact us for more information.

References

  1. Li, Y.; et al. Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice. Annals of Allergy, Asthma & Immunology. 2012, 109(3): 201-207.
  2. Zhang, S.L.; et al. Influence of microbiota on intestinal immune system in ulcerative colitis and its intervention. Frontiers in immunology. 2017, 8: 1674.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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