Datasheet

Ruminococcus gnavus; 29149 (CAT#: LBSX-0522-GF68)

Ruminococcus gnavus was isolated from human faeces.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

CAT	Size	Price	Quantity
LBSX-0522-GF68

Product Information
Product Overview	Ruminococcus gnavus was isolated from human faeces.
Target	Ruminococcus
Genus	Ruminococcus
Strain Designation	VPI C7-9
Application	Study and research
Type Strain	Yes
Culture Medium	Columbia blood agar
Culture Conditions	37°C; Anaerobic
Source	Human faeces
Risk Group	1
Product Format	Freeze-dried
Packaging	Ampoule tube
Storage	-80°C
Shelf Life	6 years

Target Introduction
Introduction	Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, Gram-positive gut microbes. One or more species in this genus are found in significant numbers in the human gut microbiota.
Alternative Names	Ruminococcus gnavus; 29149

FAQs Published Data Customer Reviews Related Products

How should Ruminococcus gnavus be stored?
Ruminococcus gnavus should be stored under anaerobic conditions to maintain viability. Use sterile butyl rubber stoppers on test tubes to retain an anaerobic gas headspace, and store pre-reduced media properly to avoid oxidation.
What type of media is recommended for culturing Ruminococcus gnavus?
Freshly prepared pre-reduced media is recommended. The use of a color indicator like resazurin in the media helps ensure anaerobic conditions. Pink coloration indicates oxidation, suggesting the media should be discarded.
What are the culture conditions of Ruminococcus gnavus?
Ruminococcus gnavus thrives in strictly anaerobic conditions with a temperature range of 37°C. It is important to monitor and maintain these conditions to ensure robust bacterial growth.
What methods are used to verify the identity of Ruminococcus gnavus?
Whole-genome sequencing is commonly used to verify the identity of Ruminococcus gnavus. This ensures the accuracy and reliability of the bacterial strain being used in research.
What are the key parameters to monitor during a study using Ruminococcus gnavus?
Key parameters include growth rate, gene expression profiles, metabolic activity, and interaction with mucin glycans. These metrics help understand the bacterial role in gut health and disease.

Ruminococcus-gnavus-29149-1

Analysis of PSA-NCAM-positive cells in the SGZ of Rg-mice and GF mice

The research explored the influence of Ruminococcus gnavus 29149 on gut-brain communication, focusing on its impact on mucin glycosylation, metabolite production, and neurogenesis in gnotobiotic mice. Mice monocolonized with R. gnavus showed significant alterations in sialic acid derivatives in the cecum, blood, and brain, with decreased sialylation in intestinal mucins compared to germ-free mice. Notably, metabolites associated with brain function, such as tryptamine and indolacetate, were elevated in the cecal content of the R. gnavus-colonized mice. Additionally, these mice displayed a significant reduction in PSA-NCAM immunoreactive granule cells in the dentate gyrus, coupled with increased phagocytic microglia, indicating enhanced neurogenesis and synaptic plasticity. Behavioral tests suggested an improvement in spatial working memory but no changes in other cognitive functions. This study provides insights into how R. gnavus-derived metabolites may regulate brain function by modulating granule cell development and synaptic plasticity, highlighting the potential role of gut microbiota in neurological health.

Coletto, E., Latousakis, D., et al. The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain. Gut Microbes. 2022, 14(1): 2073784.

Exceptional Quality and Consistency
The Ruminococcus gnavus; 29149 from Creative Biolabs consistently shows high viability and purity, making it an invaluable resource for gut microbiome research and drug development.
Superior Performance in Inflammation Studies
Utilizing Ruminococcus gnavus; 29149 has significantly enhanced our studies on intestinal inflammation, providing reliable and reproducible results compared to other suppliers' strains.
Enhanced Metabolic Pathway Analysis
The use of Ruminococcus gnavus; 29149 has markedly improved the analysis of metabolic pathways, offering unparalleled insights and consistent outcomes in our research projects.
Highly Recommended for Microbiome Research
Ruminococcus gnavus; 29149 from Creative Biolabs offers superior strain stability and purity, proving essential in our gut microbiota modulation studies and yielding consistent, high-quality data.
Outstanding Strain for Gut Microbiota Studies
Creative Biolabs' Ruminococcus gnavus; 29149 is an exceptional choice for gut microbiota research, providing consistent results and superior performance in our comparative studies.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.