Lactobacillus salivarius is a probiotic bacteria species that has been found to live in the gastrointestinal tract and exert a range of therapeutic properties including suppression of pathogenic bacteria.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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LBGF-0722-GF94 |
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Product Information | |
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Product Overview | Lactobacillus salivarius is a probiotic bacteria species that has been found to live in the gastrointestinal tract and exert a range of therapeutic properties including suppression of pathogenic bacteria. |
Target | Lactobacillus |
Genus | Lactobacillus |
Application | Study and research |
Culture Medium | MRS |
Culture Conditions | 37°C; Anaerobic |
Risk Group | 1 |
Product Format | Freeze-dried |
Packaging | Ampoule tube |
Storage | -80°C |
Shelf Life | 6 years |
Target Introduction | |
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Introduction | Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, convex, and translucent. Some species of Lactobacillus used commonly as probiotics. They are most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome; IBS, colic in infants, and many other conditions that involve the stomach and bowel. |
Alternative Names | Lactobacillus salivarius ; 24736 |
Lactobacillus salivarius is primarily used in research for studying its probiotic effects on gut health, its potential in modulating immune responses, and its role in inhibiting pathogenic bacteria. Researchers also investigate its applications in oral health and its impact on various gastrointestinal disorders.
Lactobacillus salivarius contributes to gut microbiota modulation by enhancing the growth of beneficial bacteria while inhibiting harmful pathogens. This strain produces bacteriocins and lactic acid, creating an environment that supports a healthy microbial balance in the gastrointestinal tract.
Key characteristics of Lactobacillus salivarius include its strong adhesion to intestinal epithelial cells, its ability to produce antimicrobial substances, and its resilience in acidic and bile environments. These traits make it a robust candidate for therapeutic applications in maintaining and restoring gut health.
When using Lactobacillus salivarius in research, it is crucial to consider its Generally Recognized As Safe (GRAS) status. Researchers should ensure proper strain identification, assess potential antibiotic resistance, and evaluate any adverse effects in both in vitro and in vivo models to ensure safety.
Lactobacillus salivarius can be used in conjunction with other probiotics in research studies to explore synergistic effects on gut health, immune modulation, and pathogen inhibition. Combining multiple strains may enhance the overall probiotic benefits and provide a broader spectrum of activity.
Significant correlations between serum hepcidin and hepatic DMT1, serum hepcidin and hepatic TfR1, and serum erythroferrone and TfR2
The study explored the impact of multistrain probiotic supplementation, including Lactobacillus salivarius W24, on iron metabolism in Wistar rats. Thirty rats were divided into three groups: a placebo group, and two probiotic groups receiving daily doses of 2.5 × 10^9 CFU and 1 × 10^10 CFU, respectively. The probiotics consisted of nine bacterial strains, with L. salivarius W24 being one of them. Over six weeks, various parameters related to iron metabolism were measured, including serum concentrations of hepcidin, lactoferrin, homocysteine, ferritin, and erythroferrone, as well as liver content of divalent metal transporter 1 (DMT1), transferrin receptors (TfR1 and TfR2), and ZRT/IRT-like protein 14 (ZIP14).
The results indicated no significant differences between the groups in terms of the measured serum concentrations and liver protein contents. However, significant correlations were noted between serum hepcidin and liver DMT1 and TfR1, and between serum erythroferrone and liver TfR2. These findings suggest that while the probiotic supplementation did not disrupt iron homeostasis or significantly alter the measured parameters, it highlighted important regulatory mechanisms involving hepcidin and erythroferrone in iron metabolism. The study concludes that multistrain probiotic supplementation, including L. salivarius W24, is safe and does not adversely affect iron balance, thereby supporting its potential use in dietary interventions.
Skrypnik, K., Bogdański, P., et al. Hepcidin and erythroferrone correlate with hepatic iron transporters in rats supplemented with multispecies probiotics. Molecules. 2020, 25(7): 1674. Distributed under Open Access license CC BY 4.0, without modification.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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