Microbial Fermentation Process Optimization Services

Creative Biolabs is a leading company in Live Biotherapeutics Products (LBPs) development. We have considerable experience from culture to product. To promote your LBP development project, fermentation process optimization services are available in Creative Biolabs. We can help you solve the challenges in LBP development with our mature fermentation platform and skilled scientists.

Background

Fermentation technology is widely used for the production of various compounds and bacteria that are applied in the energy production, pharmaceutical, chemical, and food industries. The production level of microbial fermentation not only depends on the performance of the producing strain but also requires the best environmental conditions to fully exploit its production capacities, such as the fermentation process and the fermentation medium. Different LBPs contain different organisms, therefore, it is necessary to explore the optimum fermentation process conditions for different strains.

As fermentation processes move towards low-value, high-volume models, it is imperative to maximize fermentation efficiency and minimize production costs and by-products to compete effectively with traditional methods. Therefore, in the process of medium optimization, it must be considered that microorganisms must meet the minimum growth requirements to obtain the maximum yield.

Our Microbial Fermentation Optimization Services

• Medium optimization remains one of the most critical research phenomena carried out before any large-scale metabolite production and possesses many challenges. The quantity and quality of available nutrients and the ability to successfully assimilate are major determinants of microbial nature and its metabolic activities. Optimization of the medium could improve the yield and activity of the required products.
• Two optimization schemes: We can provide you with the following two optimization schemes according to the needs of your project and the characteristics of the strains, ultimately providing you with the best formula for your products.
  1. Classical medium optimization strategies:
     Selection of carbon and nitrogen sources.
     Selection of inorganic salts.
  2. Statistical medium optimization strategies

• To achieve high quality and yield products, it is necessary to study the optimum fermentation process conditions for strain production and a reasonable fermentation process will be designed for the production of strains under the best. Cells in high-density cultures face conditions such as nutrient depletion, elevated osmotic pressures, increased viscosity, limited oxygen transfer capacity, and local as well as temporal variations in concentrations of nutrients, temperature, agitation, and pH. All these factors affect cell growth and product formation, which needs to be controlled at optimum values. The control parameters may also be switched based on the reactor conditions and specific to the process as different parameters need to be controlled at different stages of bioprocesses.
• Optimization schemes
  1. Initial pH value optimization during fermentation.
  2. Inoculum size and seed age optimization during fermentation.
  3. Temperature and dissolved oxygen optimization during fermentation.
  4. Feeding rate.
  5. Harvesting time, etc.

Creative Biolabs' Capabilities

• Develop reliable, robust, and scalable processes.
• Medium development.
• Pre-clinical material supply.
• Key process parameter identification based on process characterization/design space mapping.
• Develop process control strategies.
• Pilot scale production.
• Scale-down validation research.

Why Choose Us?

• Flexible to meet the unique needs of LBP projects.
• Cost-effective and rapid turn-key.
• Experienced in LBP development.
• High-end talents with fermentation backgrounds

Frequently Asked Questions

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.