Fermentation Process Optimization Services
Creative Biolabs is a leader company in Live Biotherapeutics Products (LBPs) development. We have considerable experience from culture-to-product. To promote your LBP development project, fermentation process optimization services are available in Creative Biolabs. We can help you solve the challenges in LBP development with our mature fermentation platform and skilled scientists.
Fermentation technology is widely used for the production of various compounds and bacteria which are applied in the energy production, pharmaceutical, chemical, and food industries. The production level of microbial fermentation not only depends on the performance of the producing strain but also requires the best environmental conditions to fully exploit its production capacities, such as the fermentation process and the fermentation medium. Different LBPs contain different organisms, therefore, it is necessary to explore the optimum fermentation process conditions for different strains.
Medium Optimization Services
As fermentation processes move towards low-value, high-volume models, it is imperative to maximize fermentation efficiency and minimize production costs and by-products to compete effectively with traditional methods. Therefore, in the process of medium optimization, it must be considered that microorganisms must meet the minimum growth requirements to obtain the maximum yield.
Medium optimization remains one of the most critical research phenomena carried out before any large-scale metabolite production and possesses many challenges. The quantity and quality of available nutrients and the ability to successfully assimilate are major determinants of microbial nature and its metabolic activities. Optimization of the medium could improve the yield and activity of the required products.
We can provide you with the following two optimization schemes according to the needs of your project and the characteristics of the strains, ultimately providing you with the best formula for your products.
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Classical Medium Optimization Strategies
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Statistical Medium Optimization Strategies
Fig.1 Schematic representation of various techniques used in optimization studies. (Singh, 2016)
Process Optimization Services
To achieve high quality and yield products, it is necessary to study the optimum fermentation process conditions for strain production and a reasonable fermentation process will be designed for the production of strains under the best.
Cells in high-density cultures face conditions such as nutrient depletion, elevated osmotic pressures, increased viscosity, limited oxygen transfer capacity, and local as well as temporal variations in concentrations of nutrients, temperature, agitation, and pH. All these factors affect cell growth and product formation, which needs to be controlled at optimum values. The control parameters may also be switched based on the reactor conditions and specific to the process as different parameters need to be controlled at different stages of bioprocesses.
Fig.2 Workflow from Proof-of-Principle Strain Development to an Optimized Conversion System for Industrial Scale-up. (Wehrs, 2019)
With our advanced fermentation equipment and experienced microbial scientists, Creative Biolabs can monitor the growth of strains in real-time and quickly obtain the growth characteristics of strains. According to your product needs, we will make the most suitable optimization scheme for your products to maximize the yield level.
Why Choose Us?
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Flexible to meet the unique needs of LBP projects.
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Cost-effective and rapid turn-key.
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Experienced in LBPs development.
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High-end talents with fermentation backgrounds.
Creative Biolabs has an advanced technology platform and offers the leading services related to LBPs. We are a multidisciplinary, qualified, and experienced team. If you want to know more, please do not hesitate to contact us for more detailed information.
References
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Singh, V.; et al. Strategies for Fermentation Medium Optimization: An In-Depth Review. Front Microbiol. 2016, 7: 2087.
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Wehrs, Maren.; et al. Engineering Robust Production Microbes for Large-Scale Cultivation. Trends Microbiol. 2019, 27: 524-537.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
