Live Biotherapeutics Drug Discovery
Backgrounds NGPs Pathway Diseases Highlights FAQs Resources
Backgrounds of Live Biotherapeutics Drugs
Live biotherapeutics are a revolutionary new class of medicines that contain a live microorganism and apply to the prevention, treatment, or cure of human diseases. With the advances in microbiota and microbiome science, increasing interest has been devoted to the discovery of live biotherapeutics drugs. Equipped with state-of-the-art technology, industry-leading expertise, and years of industry experience in drug discovery, Creative Biolabs has explored a live biotherapeutics discovery platform for product development, pre-clinical studies, and lab-scale production of live biotherapeutics drugs.
Live biotherapeutic drugs usually refer to next-generation probiotics (NGPs) or live biotherapeutic products (LBPs) in the context of a new regulatory framework. In recent decades, LBPs have shown great promise for reducing infection, stimulating innate immune responses, and modulating gastrointestinal metabolism. They are characterized by the following properties:
1) Containing live microorganisms, such as bacteria or yeast, that can be naturally occurring, recombinant, or clonally selected.
2) Having an intended therapeutic or preventive effect on human diseases.
3) Not a vaccine.
With the development of analytical methods, such as the next-generation sequencing and bioinformatics platforms, many potential NGPs have been discovered or are currently under intensive development. Our product portfolio extends from aerobic bacteria to anaerobic bacteria, depending on your research-tailored demands.
Live Biotherapeutics Drug Discovery Pathway
LBPs represent a revolutionary approach to the prevention and treatment of human diseases. Creative Biolabs has abundant experience in LBP discovery to help our customers accelerate live biotherapeutics projects. We will work with you at all stages of the LBP development process from the initiation of your project to the large-scale production of your microbes.
Fig.3 Graphical pathway for live biotherapeutic product development.1
Under healthy conditions, dynamic interactions exist between the host cells and the vast diversity of microbiota microbes to keep a balance. Once the situation of microbiota dysbiosis, lots of diseases will develop, especially chronic inflammation-related diseases, such as metabolic syndromes, cardiovascular disorders, inflammatory bowel diseases, neuropsychiatric diseases, asthma, and cancers, etc.
Highlights of Live Biotherapeutics Drug Discovery Service
Full range of live biotherapeutics drug discovery services, including strain identification and validation, analytical development and qualification, cGMP manufacturing, cell bank creation and storage, fermentation, lyophilization, etc.
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Experience in conducting different live organisms (aerobic and anaerobic bacteria, yeast).
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The abundance of microbial resources.
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Flexibility for laboratory-scale production.
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Provide a suitable quotation proposal based on the research objectives.
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Experts in the field with extensive product and preclinical development, lab-scale production of live biotherapeutics and probiotics.
Frequently Asked Questions
Are there any live biotherapeutic products approved by the FDA?
Yes, Several LBPs have been approved by the FDA.
What is the difference between probiotics and live biotherapeutics?
Probiotics: live microorganisms that, when administered in adequate amounts, confer a health benefit to the host.
Live Biotherapeutic Products: a biological product that contains live organisms; applies to the prevention, treatment, or cure of a disease or condition of human beings; and is not a vaccine. LBPs are a promising, newly emergent class of therapeutic agents that utilize live microorganisms, such as bacteria, viruses, or fungi, to prevent or treat various diseases.
What is the meaning of biotherapeutics?
It involves the treatment of disease through substances secreted by or derived from living organisms.
Resources
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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