Diseases Linked to NGPs

It is increasingly recognized that next-generation probiotics (NGPs) play important roles in the treatment of different kinds of diseases. As a leader in developing and producing novel NGPs, Creative Biolabs is committed to providing overall solutions for NGP drug discovery, focusing on NGPs isolation and identification, process development & optimization, NGPs analyses, and cGMP manufacturing for probiotics industrialization. We will work with you at all stages of your NGP development projects.

NGPs Targeting Specific Diseases

NGPs are closely related to the development of intra- and extra-intestinal, chronic inflammation-related diseases such as colitis, obesity/metabolic syndromes, diabetes mellitus, liver diseases, cardiovascular diseases, neurodegenerative diseases, and cancers. Therefore, NGPs have been considered as effective bioindicators and actors of human health. Moreover, the interactions between the gastrointestinal microbiome (NGPs) and immune milieu have been investigated as predictors and influencers of disease immunotherapy.

Our Capacity for NGPs Development

  • NGP strain isolation and definition to select “superior microbial strains” for probiotic applications
  • A thorough investigation of NGPs' metabolic profiling, antibiotic susceptibility/resistance, viability assays, biological safety, etc.
  • Host-microbe interaction tests to optimize NGPs therapeutic efficiency
  • Master and working cell bank preparation, validation, and storage
  • Fermentation and subsequent downstream purification
  • cGMP scale-up services

Highlights of NGPs Development Service

  • Flexibility - tailored strategies to meet different demands for pre-clinical, clinical, and commercial applications
  • Scalability - the strategy addresses different microbial strains
  • Optimization - continuous optimization development to enhance NGPs therapeutic efficiency
  • Cost-efficient - competitive price with high-quality services

NGPs play important roles in sustaining or reconstructing the homeostasis of intestinal microbiota, so they show great promise in clinical therapeutics. With extensive expertise in the human probiotic field, Creative Biolabs is dedicated to developing the NGPs to establish, restore, and maintain a healthy gut microbiome. If you are interested in our services, please feel free to contact us.


  1. Lin, T. L.; et al. Investiture of next generation probiotics on amelioration of diseases-Strains do matter. Medicine in Microecology. 2019, 1: 100002.

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