Akkermansia muciniphila as Next Generation Probiotics

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Next generation probiotics (NGPs), also referred to live biotherapeutic products (LBPs), can target specific diseases and can be used as a revolutionary class of medicines for therapeutic purposes. NGPs are usually derived from next-generation sequencing (NGS) and bioinformatics analysis. With our state-of-the-art technology and industry-leading expertise, Creative Biolabs has developed an unparalleled platform for NGP isolation, identification, and functional characterization. Currently, we have discovered a wide range of potential NGPs, including Akkermansia muciniphila strain, for pre-clinical, clinical, and commercial applications.

Introduction of Akkermansia muciniphila

Akkermansia muciniphila (A. muciniphila), belonging to the phylum Verrucomicrobia, is a symbiotic bacterium of the mucus layer. It has been isolated and characterized as a mucin-utilizing specialist, utilizing mucin as its sole carbon, nitrogen, and energy source. A. muciniphila is the only member of Verrucomicrobia in the intestinal tract of humans and animals and easy to detect using its 16S rRNA gene sequence, therefore, the probiotic effects of A. muciniphila including metabolic modulation, immune regulation, and gut health protection, have been widely investigated. Among the next-generation beneficial microbes that have been identified, A. muciniphila is a promising candidate.

A. muciniphila and Diseases

The colonization and abundance of A. muciniphila in the gut are closely associated with host health and diseases. Numerous studies have shown that the disturbance of A. muciniphila abundance is associated with various diseases such as metabolic syndromes, autoimmune diseases, cardiometabolic diseases, gastrointestinal disorders, and cancer.

Fig.1 Effects of A. muciniphila and derived products on host metabolism. (Cani, 2017)

Diseases	Functions of A. muciniphila
Metabolic Disease	It has been an appreciation that abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of metabolic diseases, including obesity and type 2 diabetes. Amongst, A. muciniphila shows a positive correlation between its intestinal colonization and host homeostatic metabolism. By daily supplementation of A. muciniphila for five weeks, body weight gain and fat mass were significantly alleviated. Besides, glucose tolerance and insulin sensitivity were also improved by A. muciniphila supplementation.
Autoimmune Disease	Dysbiosis of the intestinal microbiome is related to autoimmune diseases like rheumatoid arthritis (RA), type 1 diabetes (T1D), and multiple sclerosis (MS). A. muciniphila is abundantly present in the healthy human gut but is reduced in autoimmune-diseased individuals. It has shown efficacy in treating autoimmune diseases when orally administered.
Cardiovascular Disease	The pathogenesis of cardiovascular diseases (CVDs), such as hypertension and atherosclerosis, is associated with gut microbiota dysbiosis. A. muciniphila was found to improve gut barrier functions and exert protective effects against atherosclerosis and hypertension.
Gastrointestinal Disorders	Studies have revealed an inverse relationship between A. muciniphila and intestinal inflammation, such as inflammatory bowel diseases (IBD). A. muciniphila was shown to improve the gut barrier partially via its outer membrane protein Amuc_1100 that interacts with Toll-like receptor 2, revealing its potential protective pathway against IBD.
Cancer	One study showed that A. muciniphila was especially enriched in cancer patients who responded to PD-1 treatment when compared to non-responders, suggesting that A. muciniphila may enhance anticancer immunotherapy efficacy such as anti-PD-1 treatment.

NGP Discovery Services at Creative Biolabs

With industry-leading expertise and state-of-the-art single-use equipment, Creative Biolabs has pioneered the discovery of novel NGPs. Our comprehensive services include but not limited to new NGP identification, characterization, analyses & qualification, and scale-up GMP manufacturing. We will work with you at all stages of the NGP development process from the initiation of your project to the large-scale production.

muciniphila is one of the promising candidates in human NGP development and has been isolated and characterized. Based on advanced facilities, capabilities, and expertise in microbiome science, Creative Biolabs is confident in discovering more single species of NGPs targeting different diseases. If you are interested in our services, please feel free to contact us.

Related Products

CAT	Product Name	Product Overview
LBP-006FG	Akkermansia muciniphila Powder	Freeze-dried Akkermansia muciniphila Powder.
LBST-010FG	Akkermansia muciniphila; Muc	Akkermansia muciniphilawas isolated from human feces. It is a species of human intestinal mucin-degrading bacterium. It is a Gram-negative, strictly anaerobic, non-motile, non-spore-forming, oval-shaped bacterium.
LBST-011FG	Akkermansia muciniphila; YL44	Akkermansia muciniphil was isolated from wild type mouse. It is a Gram-negative, strictly anaerobic, non-motile, non-spore-forming, oval-shaped bacterium.
LBST-012FG	Akkermansia muciniphila Derrien et al.	Akkermansia muciniphila was isolated from human feces. It is a species of human intestinal mucin-degrading bacterium. It is a Gram-negative, strictly anaerobic, non-motile, non-spore-forming, oval-shaped bacterium.

Highlights of Our A. muciniphila NGPs Discovery

Experts with decades of microbiome research offer unparalleled insights into A. muciniphila applications.
State-of-the-art facilities ensure the highest quality probiotic cultures for advanced research needs.
Pioneering technology enables precise manipulation of A. muciniphila strains for specific research outcomes.
A rich portfolio of successful case studies demonstrates our commitment to supporting groundbreaking microbiome research.