Organs-on-Chip for Live Biotherapeutic Products Assessment
Creative Biolabs, the world's leading live biotherapeutics research service platform, efficiently advances the projects by delivering reliable, high-quality, and innovative technology as well as exceptional customer service.
Overview of Organ-on-Chip Technology
A central reason for the high failure rate of new drugs in clinical trials is our insufficient understanding of the fundamental human pathophysiology and the underlying mechanisms. Organ-on-a-Chip can better model the human system to pinpoint the drug targets in a controllable and traceable manner than animal models. It combines biotechnology, cell biology, biomaterials, and biomedical sciences to recapitulate an organ or tissue microenvironment. The main motivation behind multi-organs-on-chips was to include a gut part for modeling drug absorption and a liver part for modeling drug metabolism. Combinations of these components have been tested using kidney models to study drug responses and their metabolism.
Potential Applications in Live Biotherapeutics Product Screening
Organ-on-chip technology is being used to develop cost-effective in vitro models that can more reliably predict the efficacy, toxicity, and pharmacokinetics of the drug in humans, as well as for novel phenotypic screening assays.
Human organ-on-a-chip models provide a means to reproduce and pharmacologically modulate key aetiologies and clinically relevant integrated downstream responses at varying levels of complexity that is critical for reliable assessment of drug efficacy.
Organ-on-chip technology could be used to assess human-relevant drug responses for anticipated toxicities at various levels of biological complexity and to detect unanticipated off-target toxicities. Thus, Organ-on-a-chip models can be used for precise prediction and mechanistic studies of dose-limited toxicity of prospective drugs in humans, as well as for exploring new therapeutic approaches to mitigate observed toxic effects.
Organs-on-Chip Platforms at Creative Biolabs
Many skin-on-chip platforms have been developed to aid the process of drug development and testing. This model is a simple representation of the epidermis, much like a keratinocyte culture system. To gain more physiological relevance, several studies have also incorporated vascularization into skin-on-chip models that primarily utilize endothelial cells.
Intestine-on-chip platforms vary in their complexity and functionality. To further prove the generality of this platform and its analysis of the results of potential intestinal pathological physiology and drug, scientists have used the gut-on-chip to study the probiotics and pathogenic bacteria, LPS, immune cells, inflammatory cytokines, and how mechanical force alone or jointly promote intestinal inflammation, villus damage, and the integrity of the epithelial barrier.
Many liver-on-chip platforms have been developed to support a prolonged culture of hepatocytes and facilitate the study of various functions of the liver, including metabolism, detoxification, and response to drugs.
Fig.1 Microfluidic Organ-on-a-Chip platform. (Ma, 2021)
Advantages of Organs-on-Chip
Organs-on-chips also have advantages over current animal models. The optical transparency of organ-on-a-chip microdevices is another key advantage over animal models, as it allows direct real-time visualization and quantitative high-resolution analysis of various biological processes, which is not possible in animal models. Organs-on-chip can also reduce the consumption of expensive reagents, including cells, culture media, and drug compounds. Organs-on-chip could be used earlier in the drug discovery pipeline than animal models.
One of the main potential applications of organ-on-chip is to assess the safety of drugs before entering clinical trials. Outsourcing the safety assessment of live biotherapeutics to the team of Creative Biolabs experts can help you make progress faster, stay ahead of the competition, and find time to address the challenges ahead. Contact us to discuss your live biotherapeutics project by organ-on-chip technology.
Reference
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Ma, C.; et al. Organ-on-a-chip: a new paradigm for drug development. Trends in pharmacological sciences. 2021, 42(2): 119-133.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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