Live Biotherapeutics Drug Discovery Service for Helicobacter Pylori Infection
Creative Biolabs supports researchers in the fields of life sciences and live biotherapeutics by providing high-quality custom services and products. Whether you are at the forefront of academic research or pre-clinical research, we can communicate to determine a flexible solution that meets your research needs.
Overview
Helicobacter pylori (H. pylori) can affect the proliferation and apoptosis of gastric cells, and increase the biosynthesis of polyamine. This bacterium is considered to be a major cause of chronic gastritis and duodenal ulcers in children and an important co-factor in the development of gastric cancer. It is related to the occurrence of chronic gastritis, gastric adenocarcinoma, peptic ulcer, and other gastrointestinal diseases.
Fig.1 Gastrointestinal disease and H. pylori infection.
Probiotics and H. pylori Inhibition
Research has shown that various lactic acid bacteria can inhibit the growth of H. pylori. For example, Lactobacillus acidophilus: L. acidophilus strain CRL 639, L. acidophilus LB, L. acidophilus strain NAS and DDS-1; L. johnsonii La1; L. salivarius WB 1004. In vitro studies have demonstrated that L. reuteri exerts a significant inhibitory effect on H. pylori growth. Other probiotic bacteria were shown to exert an inhibitory effect on H. pylori by lactic acid- and pH-independent mechanisms.
Mechanisms of Probiotic Action on H. pylori
As an emerging adjuvant, probiotics have been used to treat infections including H. pylori. The antagonistic effect of probiotics on H. pylori is achieved through a series of interactions such as secretion of antimicrobial substances, competitive inhibition, enhancement of mucosal barrier, and regulation of immunity.
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Ingestion of exogenous lactobacilli, may enhance these protective functions in the stomach by maintaining local microbial homeostasis, reducing inflammatory processes, and/or interfering with H. pylori.
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Certain lactobacilli synthesize antimicrobial compounds related to the bacteriocin family. Bacteriocins are potential anti-H. pylori activity compounds.
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The inhibition of the H. pylori adherence.
Fig.2 Mechanisms of antagonism of probiotics against H. pylori.1
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar H. pylori Infection Research
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Research Article
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Available Services
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Probiotic containing Lactobacillus reuteri as an adjunct treatment for Helicobacter pylori infection.2
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In vitro anti-helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics.3
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Creative Biolabs knows how much you value collaboration, flexibility, and quality. Our deep team of scientists and advanced technology platforms provide us with live biotherapeutics preclinical research solutions for the biopharmaceutical industry. Our company has many years of experience in contract research services and the most advanced technology to support your research. If you are interested in our services or products, please do not hesitate to contact us for further discussion.
References
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Qureshi, Nuzhat et al. "Probiotic therapy in Helicobacter pylori infection: a potential strategy against a serious pathogen?" Applied microbiology and biotechnology vol. 103,4 (2019): 1573-1588.
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Ismail, Nur Izreena, et al. "Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double‐blind, placebo‐controlled trial." Helicobacter (2023): e13017.
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Pinchuk, Irina V., et al. "In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics." Antimicrobial agents and chemotherapy 45.11 (2001): 3156-3161.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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