Live Biotherapeutics Drug Discovery Service for Thyroid Disease
Creative Biolabs is a contract research organization focused on the early stages of drug discovery in the biotechnology and pharmaceutical industries. As a leading provider of biopharmaceutical research services to the industry, we understand that starting with the right protocol is critical to the success of your drug discovery initiative. At Creative Biolabs, we are committed to providing high-quality research services and data to enable basic life science and drug discovery research. We are the industry leader in customer-driven project design and implementation, starting and finishing with your every project requirement in mind.
Gut Microbiota and Thyroid Autoimmune Diseases
Autoimmune thyroid disease (ATD) is a prevalent autoimmune disorder. The human microbiome has emerged as a crucial regulator of health and disease, with implications for human well-being. It appears that the microbiota can influence the uptake of I- and the enterohepatic system circulation of thyroid hormones. Microbiome metabolites significantly affect thyroid function. Ongoing research primarily focuses on short-chain fatty acids (SCFAs), which possess the ability to enhance intestinal epithelial cell integrity, prevent pathological microbial invasion, regulate immune responses, and inhibit inflammatory processes. Furthermore, SCFAs play a pivotal role in regulating the balance between Th17 cells and Treg cells and are closely associated with the onset and progression of autoimmune diseases.
Fig.1 Potential relationships between alterations in gut microbiota and autoimmune thyroid disease pathogenesis.1
Techniques to Assess the Impact of Bacteria on the Autoimmune Thyroid Disease
Culturing the fecal microbial communities of healthy donors under strict anaerobic conditions captures a significant proportion of the gut microbiome and preserves the uniqueness of each donor microbiome.
Although all in vitro models have their limitations, the use of in vitro models can yield insights into Graves' disease (GD) and a better understanding of the disease.
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Cell lines
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Mucosal biopsy organ culture
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Flow models
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3D cell culture systems
Next-generation Probiotics for Thyroid Disease
GD is an autoimmune disease that often causes symptoms such as hyperthyroidism. The study demonstrated the mechanism by which Bifidobacterium longum probiotics regulate the intestinal flora of GD patients and reduce the recurrence rate and developed a potentially useful treatment for GD based on the regulation of intestinal flora.
Fig.2 The simplified diagrammatic drawing of the potential effective mechanism.2
Our Services for the Following Type/Similar ATD Research
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Research Article
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Available Services
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Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients.3
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With decades of industry experience, Creative Biolabs' highly skilled scientists are ready to begin your next-generation probiotics research project. We work closely with our clients to develop customized detailed workflows so that you understand every step of the project before the work begins. A dedicated project manager will monitor the progress of the project and communicate important details to you in real time. All of our processes are internally verified to ensure high-quality results. If you are interested in our services or products, please feel free to contact us.
References
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Sawicka-Gutaj, Nadia, et al. "Microbiota alterations in patients with autoimmune thyroid diseases: a systematic review." International Journal of Molecular Sciences 23.21 (2022): 13450.
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Huo, Dongxue, et al. "Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis." Communications Biology 4.1 (2021): 1046.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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