Live Biotherapeutics Drug Discovery Service for Antibiotic-Associated Diarrhea
Creative Biolabs provides comprehensive live biotherapeutics discovery services and potential next-generation probiotic candidate strain products to the pharmaceutical and biotechnology industries as well as academic research involving the life sciences. Our clients have recognized us as a leading CRO and long-term partner, working together on live biotherapeutics pre-clinical research services, and we are an agile and dynamic team. More than a decade of experience accelerating breakthrough discoveries for pharmaceutical and biotechnology companies around the world enables us to understand challenges well and find solutions to effectively advance your projects.
Overview
Antibiotics are known to disrupt the complex balance of gastrointestinal microbiota, allowing colonization by pathogenic organisms such as Clostridium difficile. Probiotics are living microorganisms that may prevent antibiotic-associated diarrhea (AAD) by normalizing unbalanced gastrointestinal flora. The underlying mechanism of AAD is not fully understood. It may be caused by specific intestinal pathogens (such as Clostridium perfringens, Clostridium difficile, Staphylococcus aureus, or Candida albicans), metabolic consequences of changes in gut microbiota, or direct effects of antibiotics on the mucosa. In children, two probiotics that have been proven to be effective in preventing AAD are Lactobacillus rhamnosus GG and Saccharomyces boulardii.
Probiotics in Preventing AAD
Several probiotic strains have been tested. Lactobacillus, Saccharomyces, and Bifidobacterium were the most studied probiotic genera. The hypothesis behind the use of probiotics to alleviate the symptoms and pathophysiology of GI disorders is that they can help normalize an unbalanced flora. These mechanisms include:
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Boosting Immunity
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Increasing Gut Barrier Integrity
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Producing Antimicrobial Substances
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Modulating the Gut Microbiome
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Increasing Water Absorption
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Decreasing Opportunistic Pathogen
Fig.1 Schematic model of the potential molecular mechanisms responsible for probiotic prevention of AAD.1
The use of living organisms as a treatment or prophylaxis for AAD has been tried using several species, and probiotics are widely used in Europe for diarrhea therapy. The advantages of using living microbes are that they are effective while minimizing the impact on normal intestinal microbiota and, unlike antibiotic treatments, have not been associated with serious adverse effects.
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar AAD Research
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Research Article
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Available Services
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Effects of Lactobacillus plantarum and Weissella viridescens on the gut microbiota and serum metabolites of mice with antibiotic-associated diarrhea.2
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Effects of apple juice fermented with Lactobacillus plantarum CICC21809 on antibiotic-associated diarrhea of mice.3
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Creative Biolabs' emphasis on scientific expertise, technology, innovation, and problem-solving, as well as our strong foundation in sustainability and compliance, makes us the partner of choice for many large pharmaceutical and biotech companies. We believe that long-term partnerships can be fostered and nurtured through work built on speed, adaptability, communication, and clarity of collaboration. If you are interested in our live biotherapeutics research services, please do not hesitate to contact us for more details.
References
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Mekonnen, Solomon A., et al. "Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea." Current opinion in biotechnology 61 (2020): 226-234.
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Yan, Zhiwei, et al. "Effects of Lactobacillus plantarum and Weissella viridescens on the Gut Microbiota and Serum Metabolites of Mice with Antibiotic-Associated Diarrhea." Nutrients 15.21 (2023): 4603.
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Guo, Xin, et al. "Effects of apple juice fermented with Lactobacillus plantarum CICC21809 on antibiotic-associated diarrhea of mice." Journal of Functional Foods 99 (2022): 105334.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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