Live Biotherapeutics Drug Discovery Service for Wound Healing
The United States-based biotechnology company, Creative Biolabs services a diverse clientele comprising academic research laboratories, biotechnology firms, and delivery of high-quality customized solutions.
Overview
Wound healing is a physiological response of the body to tissue injury and plays a crucial role in replacing damaged tissue. Probiotics produce valuable compounds with antimicrobial and anti-inflammatory activities, immunomodulatory effects, and angiogenic properties that promote wound healing. Any intervention that promotes healthy bacteria and reduces pathologic bacteria should aid wound healing. Therefore, probiotics have shown certain therapeutic effects in promoting skin wound healing, regulating glucose homeostasis, reducing inflammation, and improving various skin conditions. Because injury and activation of the immune response result in local microbiota disturbance in the wound, the addition of topical probiotics may be a means of preventing infection, regulating inflammation, and potentially promoting healing.
Probiotics and Wound Healing
The antibacterial mechanism of probiotics is through the regulation of antimicrobial peptides (AMPs). AMPs are produced by various cells and help maintain the integrity of the skin. Probiotics have shown the ability to improve wound healing in various human and animal models. Some commensal strains can produce their cathelicidin, which can influence human cathelicidin production and act synergistically on wound healing and protection against pathogenic bacteria such as Staphylococcus aureus. Probiotics are also involved in improving the process of skin differentiation and keratinization, regulating the skin's immune response, and participating in the skin healing process.
Fig.1 Proven and possible mechanisms of action of probiotics' antagonistic effects.1
In addition to inhibiting elastase, biofilm, and acylhomoserine lactone production by Pseudomonas spp. in vitro, Lactobacillus plantarum has also demonstrated the ability to inhibit Pseudomonas and enhance tissue repair in a mouse model of burn injury.
Mice were administrated with a probiotic strain of Escherichia coli fused to epidermal growth factor (EGF), and accelerated epithelial wound healing and reduced disease severity were observed compared with controls, suggesting that the beneficial effects of probiotics can be further enhanced by engineering the addition of various growth factors.
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar Wound Healing Research
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Research Article
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Available Services
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Exploring the wound healing, anti-inflammatory, anti-pathogenic, and proteomic effects of lactic acid bacteria on keratinocytes.2
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Antimicrobial activity of lactic acid bacteria against skin pathogens
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Insight into the beneficial role of Lactiplantibacillus plantarum supernatant against wound healing in A549 cells and BALB/c mice.3
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Antibacterial activity study
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Hemolytic assay for toxicity testing of probiotic
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Cytokine analysis
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Creative Biolabs' expertise in live biotherapeutics and probiotics will enable us to provide customized solutions for our clients. Our cooperation projects include microbial challenge research, lab-scale probiotic production, drug resistance analysis, microbial limit detection of drugs, etc., all of which have been well received by customers. If one of our services or products meets the needs of your research project and you are selecting a supplier, please do not hesitate to contact us.
References
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Fijan, Sabina, et al. "Efficacy of using probiotics with antagonistic activity against pathogens of wound infections: an integrative review of literature." BioMed research international 2019.1 (2019): 7585486.
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Brandi, Jessica, et al. "Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes." Scientific reports 10.1 (2020): 11572.
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Dubey, Ashish Kumar, et al. "Insight into the beneficial role of Lactiplantibacillus plantarum supernatant against bacterial infections, oxidative stress, and wound healing in A549 cells and BALB/c mice." Frontiers in Pharmacology 12 (2021): 728614.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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