Bacteroides dorei was isolated from human feces. It is an Gram-negative, rod-shaped bacteria that contributes to normal intestinal functionality.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
Product Information
Product Overview
Bacteroides dorei was isolated from human feces. It is an Gram-negative, rod-shaped bacteria that contributes to normal intestinal functionality.
Target
Bacteroides
Genus
Bacteroides
Application
Study and research
Type Strain
Yes
Culture Medium
36
Culture Conditions
37°C; Anaerobic
Source
Human feces
Risk Group
1
Product Format
Freeze-dried
Packaging
Ampoule tube
Storage
-80°C
Shelf Life
6 years
Target Introduction
Introduction
Bacteroides is a group of promising candidates that has attracted major attentions from scientists as model organisms or community for the investigations of the intestinal microbiota field, due to their powerful adaption characteristics in the host and especially the underlying benefits. Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species. Bacteroides; order is the most abundant group of Gram-negative bacteria which flourish in the human intestine at high densities of 109-1011 CFU per gram of feces, and constitutes over 30 species which are more closely related than members in other bacteria orders. And, Bacteroides is considered as one of the major genera of the core microbiota module, of which species with relative abundance of over 1% refers to B. uniformis, B. vulgatus, B. caccae, and B. thetaiotaomicron. In addition to the unique physiological characteristics and the special ecological dynamics, Bacteroides species are under investigations for their underlying beneficial dialogues with the host. Bacteroides species to be considered as next-generation probiotics, and the application of which in prevention or intervention in dysbiosis of gut microbiota and the associated disorders requires further investigations in the modulatory mechanisms and safety evaluation. Bacteroides is one of the dominant contributors of SCFA among the intestinal commensals, mostly in the form of acetate and propionate. Accumulated acetate blocks the transportation of toxins between gut lumen and blood, while propionate is capable of inducing the apoptosis of human colon carcinoma cells, and thus avoids the formation of tumors. Moreover, Vitamin K, which is mainly synthesized by gut microbiota candidates such as Bacteroides, can help prevent or treat osteoporosis by increasing bone mineral density.
Alternative Names
Bacteroides dorei
FAQsPublished Data Customer Reviews Related Products
What are the optimal growth conditions for Bacteroides dorei?
Bacteroides dorei thrives under anaerobic conditions at 37°C. It can metabolize a variety of sugars such as glucose, sucrose, and lactose, producing acids which are indicative of its growth under laboratory conditions.
How should Bacteroides dorei be stored for long-term viability?
Bacteroides dorei should be stored at -80°C in an appropriate cryoprotective medium such as glycerol or a commercially available cryopreservation solution to maintain cell viability over long periods.
Can Bacteroides dorei be co-cultured with other gut microbes?
Yes, Bacteroides dorei can be co-cultured with other gut microbiota. However, it's important to select compatible microbial strains and growth conditions that support the survival and interaction of all species involved, mimicking the gut environment as closely as possible.
How is Bacteroides dorei relevant in immunological research?
Bacteroides dorei has been shown to play a role in immune system modulation. It can influence immune-related adverse events in treatments such as immune checkpoint blockade therapy, making it a significant subject of study in immunology and microbiome research.
How can the metabolic activity of Bacteroides dorei be assessed in vitro?
The metabolic activity of Bacteroides dorei can be assessed by measuring the production of fermentation end-products like short-chain fatty acids, monitoring pH changes in the culture medium, or using gas chromatography to analyze metabolic gases produced during fermentation.
Bacteroides dorei/vulgatus predicts autoimmunity before appearance of any single autoantibody
The research detailed in the document focuses on the prevalence and implications of Bacteroides dorei in Finnish children at high risk for Type 1 diabetes (T1D). It explores how changes in the gut microbiome, particularly the dominance of Bacteroides dorei, may correlate with the onset of autoimmunity leading to T1D. The research involved high-throughput 16S rRNA gene sequencing to analyze the microbiomes of 76 children from birth up to 2.2 years, observing the gut microbial composition over time. Experimental data revealed that Bacteroides dorei was significantly more abundant in children who later developed T1D-related autoimmunity compared to those who remained healthy. This difference was noted particularly after the introduction of solid foods, aligning with the peak abundance of Bacteroides dorei at about 7.6 months-several months before the first detection of T1D autoantibodies. The study suggests that early microbiome alterations could potentially serve as indicators for predicting T1D autoimmunity, offering insights into early diagnostics and preventive strategies against T1D in genetically susceptible individuals.
Davis-Richardson, A. G., Ardissone, A. N., et al. Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes. Frontiers in microbiology. 2014, 5: 678. Distributed under Open Access license CC BY 4.0, without modification.
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