Bacteroides vulgatus is a type strain.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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LBST-026FG |
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Product Information | |
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Product Overview | Bacteroides vulgatus is a type strain. |
Target | Bacteroides |
Genus | Bacteroides |
Application | Study and research |
Type Strain | Yes |
Culture Medium | Modified reinforced clostridial agar |
Culture Conditions | 37°C; Anaerobic |
Risk Group | 2 |
Product Format | Freeze-dried |
Packaging | Ampoule tube |
Storage | -80°C |
Shelf Life | 6 years |
Target Introduction | |
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Introduction | Bacteroides is a group of promising candidates that has attracted major attentions from scientists as model organisms or community for the investigations of the intestinal microbiota field, due to their powerful adaption characteristics in the host and especially the underlying benefits. Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species. Bacteroides; order is the most abundant group of Gram-negative bacteria which flourish in the human intestine at high densities of 109-1011 CFU per gram of feces, and constitutes over 30 species which are more closely related than members in other bacteria orders. And, Bacteroides is considered as one of the major genera of the core microbiota module, of which species with relative abundance of over 1% refers to B. uniformis, B. vulgatus, B. caccae, and B. thetaiotaomicron. In addition to the unique physiological characteristics and the special ecological dynamics, Bacteroides species are under investigations for their underlying beneficial dialogues with the host. Bacteroides species to be considered as next-generation probiotics, and the application of which in prevention or intervention in dysbiosis of gut microbiota and the associated disorders requires further investigations in the modulatory mechanisms and safety evaluation. Bacteroides is one of the dominant contributors of SCFA among the intestinal commensals, mostly in the form of acetate and propionate. Accumulated acetate blocks the transportation of toxins between gut lumen and blood, while propionate is capable of inducing the apoptosis of human colon carcinoma cells, and thus avoids the formation of tumors. Moreover, Vitamin K, which is mainly synthesized by gut microbiota candidates such as Bacteroides, can help prevent or treat osteoporosis by increasing bone mineral density. |
Alternative Names | Bacteroides vulgatus |
To ensure maximum viability, Bacteroides vulgatus should be cultured under anaerobic conditions at 37°C using pre-reduced, anaerobically sterilized (PRAS) culture media. It's crucial to monitor the culture's pH and nutrient levels to maintain optimal growth conditions.
Genetic stability of Bacteroides vulgatus can be assessed by regular PCR checking for key genetic markers and sequencing as needed. This ensures that the strain maintains its characteristics throughout the duration of the experiment.
The Bacteroides vulgatus strain from Creative Biolabs is rigorously characterized for genetic stability and purity, ensuring high quality and reproducibility for sensitive research applications. Each batch is tested to meet stringent quality control standards, differentiating it from potentially variable strains from other sources.
Creative Biolabs offers detailed product documentation and expert consultation to assist researchers in using Bacteroides vulgatus effectively. Support includes troubleshooting tips, optimization of experimental conditions, and custom services for strain modification or custom growth media formulations.
B. vulgatus involves in tissue inflammatory inhibition and immune homeostasis
The study focuses on Bacteroides vulgatus Eggerth and Gagnon, examining its role in influencing the gut microbiome and its implications for human health and disease. Specifically, the study investigates the effect of this bacterial species on the production of short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, which are critical for maintaining gut health and preventing diseases. The research demonstrates that Bacteroides vulgatus has significant capabilities to ferment carbohydrates, contributing to the production of SCFAs that support gut barrier integrity and suppress inflammatory responses.
Experimentally, the data highlighted the bacteria's impact on reducing inflammation in models of diseases such as colorectal cancer and inflammatory bowel disease (IBD). It was shown that the presence of Bacteroides vulgatus in the gut microbiota increases SCFA levels, which are associated with protective effects against the development of colon cancer by inducing apoptosis of tumor cells. Additionally, the research discusses how this bacterium modulates the immune system by influencing the levels of anti-inflammatory cytokines, thereby preventing excessive immune responses that can lead to chronic inflammation. Through these mechanisms, Bacteroides vulgatus Eggerth and Gagnon emerges as a potential therapeutic agent for gastrointestinal health and disease prevention.
Wang, C., Zhao, J., et al. Roles of intestinal bacteroides in human health and diseases. Critical reviews in food science and nutrition. 2021, 61(21): 3518-3536.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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