Creative Biolabs isolates and enriches S. dentisani from dental plaque or existing strain collections under strictly controlled conditions. We perform strain verification, genotype/phenotype confirmation, and high-throughput screening to prioritize S. dentisani candidates with desirable pH-buffering, bacteriocin production, and biofilm-interaction properties for downstream development.
Using standardized in vitro models, S. dentisani is profiled for arginine metabolism, ammonia generation, and lactate consumption, as well as its capacity to modulate local pH and interfere with biofilm formation by cariogenic organisms. Mechanism-of-action studies link S. dentisani activity to measurable shifts in microbial composition and physicochemical parameters.
We design targeted antimicrobial susceptibility panels for S. dentisani, including conventional antibiotics and selected antiseptic agents. Minimal inhibitory concentration (MIC) and growth-curve assays help characterize intrinsic resilience and ensure that S. dentisani-based concepts remain compatible with common oral hygiene regimens and manufacturing decontamination strategies.
Creative Biolabs develops and optimizes fermentation processes tailored to S. dentisani, from small-scale bioreactors to lab-scale production. We fine-tune medium composition, pH control, aeration/microaerophilic conditions, and feeding strategies to achieve stable biomass yields and consistent metabolic profiles suitable for subsequent formulation work.
S. dentisani is sensitive to environmental stressors, requiring carefully engineered stabilization strategies. Our team screens cryoprotectants, lyoprotectants, and storage conditions to maintain S. dentisani viability, functional activity, and genetic stability over time, supporting long-term banking and shipment under research-grade quality systems.
Creative Biolabs designs prototype formulations incorporating S. dentisani into dosage forms such as gels, lozenges, and powder premixes for research use. We evaluate excipient compatibility, moisture and oxygen sensitivity, and viability maintenance, generating data packages that inform later scale-up and product design discussions.
To support oral hygiene and mucosal delivery concepts, S. dentisani formulations undergo dissolution and release profiling in simulated saliva and oral biofilm-mimicking media. We monitor S. dentisani release kinetics, survival, and functional output over time, providing key parameters for optimizing residence time and local exposure in experimental models.
Creative Biolabs performs stability studies to evaluate how S. dentisani responds to temperature shifts, humidity, oxygen exposure, and storage conditions relevant to research-grade formulations. These controlled assays determine viability, metabolic activity, and key functional traits over time, ensuring that S. dentisani remains consistent, predictable, and suitable for downstream experimental applications.
