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Advanced Neurological Disorder Animal Model Service for Probiotic Efficacy Evaluation

Welcome to Creative Biolabs, your premier partner in cutting-edge preclinical research. We specialize in providing comprehensive and advanced animal model services for evaluating the efficacy of probiotics in neurological disorders. With the burgeoning understanding of the gut-brain axis, the potential of probiotics to mitigate and treat neurological conditions is a frontier ripe for exploration. Our state-of-the-art facilities, expert team, and meticulous methodologies are designed to provide you with robust, reliable, and actionable data to accelerate your probiotic research and development. Request a quote

Fig.1 Metabolic Disorder animal models for probiotic efficacy evaluation. (Creative Biolabs Authorized)

Overview

Our service focuses on utilizing carefully selected and validated animal models of various neurological disorders to assess the therapeutic potential of probiotic interventions. We understand that the interplay between the gut microbiome, immune system, and central nervous system is complex. Therefore, our approach is multi-faceted, encompassing behavioral, biochemical, histological, and molecular analyses to provide a holistic view of probiotic efficacy. From initial screening to in-depth mechanistic studies, we are equipped to support your research at every stage.

Comprehensive Neurological Disorder Animal Model Services for Probiotic Efficacy Evaluation

Workflow

Fig.2 The workflow for the probiotic efficacy evaluation in Metabolic Disorder animal models. (Creative Biolabs original)

Service Details

Animal Models
Administration
Analysis
Samples
Deliverables
Turnaround Time

Animal Models

  • Neurodegenerative Disorders
    • Alzheimer's Disease models
    • Parkinson's Disease models
    • Huntington's Disease models
    • Amyotrophic Lateral Sclerosis (ALS) models
  • Neurodevelopmental Disorders: Autism Spectrum Disorder (ASD) models
  • Psychiatric Disorders
    • Depression models
    • Anxiety models
  • Custom Model Development
    We can work with you to develop or adapt specific animal models to meet your unique research objectives.

Probiotic Administration and Dosing Regimen Design

  • Oral gavage, dietary supplementation, or other appropriate routes.
  • Single-strain, multi-strain, or synbiotic formulations.
  • Acute or chronic administration protocols tailored to the study design.

Comprehensive Efficacy Evaluation Parameters

  • Behavioral Phenotyping
    • Cognition: Morris Water Maze, Novel Object Recognition, Fear Conditioning, Y-maze, Radial Arm Maze.
    • Motor Function: Rotarod, Grip Strength, Open Field Locomotor Activity, Pole Test.
    • Anxiety/Depression: Elevated Plus Maze, Open Field Test, Forced Swim Test, Tail Suspension Test.
    • Social Behavior: Three-Chamber Social Interaction Test.
    • Repetitive Behaviors: Marble Burying Test, Self-grooming.
    • Seizure Activity Monitoring.
  • Biochemical and Molecular Analysis
    • Inflammatory Markers: Cytokine profiling, chemokines, C-reactive protein (CRP) in brain tissue, serum, and CSF.
    • Oxidative Stress Markers: Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) levels.
    • Neurotransmitter Levels: Serotonin, dopamine, norepinephrine, GABA, glutamate in relevant brain regions.
    • Neurotrophic Factors: BDNF, NGF, GDNF expression levels.
    • Synaptic Plasticity Markers: PSD-95, Synaptophysin expression.
    • Apoptosis Markers: Caspase-3, Bcl-2, Bax expression.
    • Pathology-Specific Markers: plaques, tau phosphorylation, α-synuclein aggregation, myelin basic protein (MBP) in relevant models.
    • Gut Permeability Markers: Zonulin, occludin, claudin expression in intestinal tissue, FITC-dextran permeability assay.
    • Short-Chain Fatty Acids (SCFAs): Butyrate, propionate, and acetate quantification in gut contents, serum, and brain tissue.
  • Histopathological and Immunofluorescence Analysis
    • Neuronal Viability and Morphology: H&E staining, Nissl staining.
    • Neuroinflammation: Microglial activation (Iba1), astrogliosis (GFAP) staining.
    • Synaptic Density: Synaptophysin, PSD-95 staining.
    • Specific Protein Aggregates: Thioflavin S/T staining for amyloid plaques, immunohistochemistry for specific pathological proteins.
    • Gut Microbiome Analysis: FISH, 16S rRNA gene sequencing (amplicon sequencing), metagenomic sequencing for comprehensive microbiome profiling.
    • Mucin Layer Integrity: Alcian blue staining.
  • Metabolomics and Proteomics (Optional Add-on)
    Advanced profiling of metabolites and proteins in biological samples to identify novel biomarkers and pathways influenced by probiotics.

Sample Information & Submission

Clients are required to provide their probiotic strains (live cultures, lyophilized powder, or specified formulations) with accompanying Certificates of Analysis (CoA) for identity, purity, and viability.

Deliverables

  • Accuracy and Reproducibility: Our strict quality control measures ensure the highest level of accuracy and reproducibility in all experimental procedures and data.
  • Timeliness: We are committed to delivering results within the agreed-upon turnaround times.
  • Confidentiality: All client information and research data are treated with the utmost confidentiality.
  • Regulatory Compliance: All studies are conducted in compliance with relevant animal welfare regulations and guidelines.

Turnaround Time

Turnaround times vary depending on the complexity of the study design, the duration of probiotic intervention, and the number of assays requested. A detailed timeline will be provided with your customized proposal. Typically, studies can range from 8-16 weeks for core experimental work, with an additional 4-6 weeks for comprehensive data analysis and report generation.

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Advantages of Partnering with Creative Biolabs

Expertise in Gut-Brain Axis Research

Our team comprises experienced neuroscientists, microbiologists, and pharmacologists with deep knowledge of the gut-brain axis and neurological disorders.

State-of-the-Art Facilities

Our vivarium and laboratories are equipped with the latest technology for animal housing, behavioral testing, and advanced analytical techniques.

Customized Study Design

We offer flexible and tailored study designs to meet your specific research objectives and budget.

Comprehensive Data Generation

From behavioral phenotyping to multi-omics analysis, we provide a holistic view of probiotic efficacy.

High-Quality, Reproducible Results

Our rigorous quality control and standardized protocols ensure reliable and defensible data.

Ethical Animal Care

We are fully committed to the highest standards of animal welfare and ethical research practices.

Dedicated Project Management

You will be assigned a dedicated project manager to ensure smooth communication throughout the research process and to provide the latest information on time.

Accelerated Drug Discovery

Our services help you efficiently screen and validate promising probiotic candidates, saving time and resources in your R&D pipeline.

Fig.3 Advanced technical platforms are used for probiotic efficacy evaluation. (Creative Biolabs Authorized)

Applications

  • Probiotic Developers: Companies developing novel probiotic strains or formulations for neurological health.
  • Pharmaceutical and Biotech Companies: Exploring microbiome-based therapies for neurodegenerative, neurodevelopmental, and psychiatric disorders.
  • Academic Researchers: Investigating the fundamental mechanisms of the gut-brain axis and probiotic intervention.
  • Nutraceutical and Functional Food Companies: Substantiating health claims for probiotic-enriched products targeting cognitive function, mood, and stress.

Mechanism of Action: How Probiotics Influence Neurological Health

  • Modulation of the Gut Microbiota: Probiotics can restore microbial balance, increase beneficial bacteria, and reduce pathogenic organisms, thereby influencing the production of neuroactive metabolites.
  • Reduction of Systemic and Neuroinflammation: Probiotics can exert anti-inflammatory effects by modulating immune cell activity and cytokine production, reducing inflammatory signaling that contributes to neurological pathology.
  • Enhancement of Gut Barrier Integrity: By strengthening the intestinal barrier, probiotics can reduce "leaky gut" and prevent the translocation of harmful substances into the bloodstream and subsequently to the brain.
  • Production of Neurotransmitters and Neurotrophic Factors: Certain probiotic strains can directly produce or influence the production of neurotransmitters (e.g., GABA, serotonin) and neurotrophic factors (e.g., BDNF), which are crucial for neuronal function and survival.
  • Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis: Probiotics can influence stress responses and anxiety-related behaviors by modulating the HPA axis.

Partner with Creative Biolabs to gain critical insights into the efficacy of your probiotic interventions for neurological disorders. Our expertise, advanced models, and commitment to quality will accelerate your research and development efforts. Contact us today for a confidential consultation and a customized proposal.

FAQs

What types of probiotics can you test?

We can test a wide range of probiotic strains, including Lactobacillus, Bifidobacterium, Saccharomyces, next-generation new type of probiotics, and multi-strain formulations. We would like you to provide us with a Certificate of Analysis (CoA) regarding the probiotic materials you are using.

Do you offer germ-free or gnotobiotic animal models?

Yes, we have capabilities for germ-free or gnotobiotic studies to investigate the precise role of specific microbial strains in neurological disorders. This can be discussed during the initial consultation.

What is the typical cost of a study?

The cost varies significantly depending on the complexity of the study design, the number of animals, the duration, and the assays requested. After the initial consultation, we will provide a personalized solution.

Can you help with regulatory submissions?

While we do not directly assist with regulatory submissions, the comprehensive data and detailed reports we provide are designed to support your regulatory filings.

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