Live Biotherapeutics Drug Discovery Service for Hand, Foot, and Mouth Disease (HFMD)
Overview
Hand, foot, and mouth disease (HFMD) is an acute gastrointestinal infectious disease caused by enterovirus, which mainly occurs in children under 10 years old. The main clinical signs of HFMD are blisters or rashes on the hands, feet, buttocks, and mouth. The pathogens of HFMD are mainly enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), which target the gastrointestinal epithelium and use intestinal bacteria to proliferate, cause disease, and spread, thus leading to the occurrence and development of the disease. Probiotics and prebiotics have been demonstrated to be beneficial for intestinal diseases by several studies and are widely used as supplements to nutritional strategies aimed at enhancing intestinal immunity. Currently, researchers are considering the use of probiotics and prebiotics to prevent HFMD.
Probiotics for HFMD Therapy
The results of the study showed that oral administration of Golden Bifid reduced the symptoms of severe HFMD. Golden Bifid, also known as Lactobacillus bifidobacterium triple viable tablets, is mainly composed of Lactobacillus bulgaricus, Bifidobacterium longum, Streptococcus thermophilus, and probiotic factors that promote the growth and reproduction of human intestinal tract to supplement intestinal probiotics. Studies have shown that they inhibit the activation of four serum proinflammatory factors by effectively reducing the expression levels of IL-1β, TNF-α, IL-6, and IFN-γ in serum, thereby alleviating inflammation. Golden Bifid can effectively alleviate the clinical symptoms of severe HFMD, maintain intestinal immunity and anti-inflammatory response, and improve intestinal barrier function, indicating that intestinal probiotics are safe and effective in the treatment of severe HFFMD. The HFMD virus is vulnerable to attack under acidic conditions, and researchers found that kombucha has effective HFMD antiviral activity due to its symbiotic probiotic components, namely yeast, and xylobacter, which have very high acidic activity. The reduced abundance of Prevotella and Clostridium_XIVa, which can produce SCFAs, may be an important part of future research on the microecological mechanisms and treatment of HFMD infants.
Our Probiotic Services for HFMD Research
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Research Articles
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Available Services
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Changes in the intestinal microbiota of children with hand, foot, and mouth disease under 3 years old.1
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Evaluation of gut microbial diversity and correlation in asymptomatic and symptomatic patients with hand, foot and mouth disease.2
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Antiviral activity of Lactobacillus reuteri protects against Coxsackievirus A and Enterovirus 71 infection in human skeletal muscle and colon cell lines.3
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Immunostaining assay
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Cell viability assay
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Antiviral activity assays
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Virus-bacteria binding assay
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Probiotic Products for HFMD Research
Creative Biolabs is a global CRO company providing comprehensive cellular and molecular biology, microbiology, and other services to pharmaceutical, biotechnology, medical device, and academic research institutions. For more than 10 years, we have been at the forefront of technology, committed to providing high-quality expert services in multiple research areas, and our fundamental mission is to help our clients maximize the return on their R&D investment. All of our research and proprietary information is strictly confidential at all times. Contact us from now on, to establish our cooperation and communication relationship, we will continue to provide you with valuable advice and personalized solutions.
References
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Zhu, Su Yue, et al. "Changes in the intestinal microbiota of children with hand, foot, and mouth disease under 3 years old." Medicine 102.18 (2023).
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Jin, Hongwei, et al. "Evaluation of gut microbial diversity and correlation in asymptomatic and symptomatic patients with hand, foot and mouth disease." (2023).
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Ang, Lei Yin Emily, et al. "Antiviral activity of Lactobacillus reuteri Protects against Coxsackievirus A and Enterovirus 71 infection in human skeletal muscle and colon cell lines." Virology journal 13 (2016): 1-12.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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