Sutterella wadsworthensis is a Gram-negative rod bacteria from the genus Sutterella.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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LBGF-0722-GF106
Product Information
Product Overview
Sutterella wadsworthensis is a Gram-negative rod bacteria from the genus Sutterella.
Target
Sutterella
Genus
Sutterella
Application
Study and research
Culture Medium
Chocolate agar
Culture Conditions
37°C; Anaerobic
Risk Group
1
Product Format
Freeze-dried
Packaging
Ampoule tube
Storage
-80°C
Shelf Life
6 years
Target Introduction
Introduction
Sutterella is a genus of Gram-negative, anaerobic, non-spore-forming bacteria of the family Sutterellaceae which belongs to the class Betaproteobacteria; they were isolated from human faeces.
Alternative Names
Sutterella wadsworthensis
FAQsPublished Data Customer Reviews Related Products
What are the optimal growth conditions for Sutterella wadsworthensis?
Sutterella wadsworthensis thrives in microaerophilic conditions with an oxygen concentration of 2-6%. It grows well on nutrient-rich media and can withstand bile, which is crucial for its survival in the gastrointestinal tract. Optimal growth is observed at 37°C, and it does not require carbohydrate fermentation for energy, relying instead on amino acid metabolism.
What are the primary research applications of Sutterella wadsworthensis?
Sutterella wadsworthensis is extensively studied in the context of gastrointestinal health, particularly inflammatory bowel diseases (IBD) and its potential role in modulating gut microbiota. It is also being investigated for its interactions with the immune system and its possible implications in autism spectrum disorders. These research applications aim to elucidate its role in human health and disease.
How is Sutterella wadsworthensis identified and characterized in laboratory settings?
Identification of Sutterella wadsworthensis typically involves 16S rRNA gene sequencing, which distinguishes it from closely related species. Additionally, biochemical assays to test for bile resistance, nitrate reduction, and lack of carbohydrate fermentation are used. Advanced techniques like PCR and mass spectrometry may also be employed for more detailed characterization.
What are the significant phenotypic characteristics of Sutterella wadsworthensis?
Sutterella wadsworthensis is a Gram-negative, rod-shaped bacterium that is bile-resistant and asaccharolytic. It is nitrate-positive and urease-negative, with a unique cell wall fatty acid composition. These characteristics help differentiate it from other similar bacteria and are essential for understanding its role in the gut environment.
How does Sutterella wadsworthensis interact with the host's immune system?
Studies suggest that Sutterella wadsworthensis can modulate the host's immune responses, potentially influencing inflammation in the gut. It adheres to mucus and extracellular matrix proteins, which may help it colonize and interact with the host tissues. These interactions are being investigated to understand their implications in diseases like IBD and autism.
Phylogenetic tree constructed using nearly full-length (1400 bp) sequences of the 16S rRNA gene of S. wadsworthensis strains from UC and controls alongside other Sutterella sequences available in GenBank
The study investigated the potential role of Sutterella wadsworthensis in inflammatory bowel disease (IBD). Twenty-six clinical isolates of S. wadsworthensis were obtained from colonoscopy samples of 134 adults and 61 pediatric patients, including 69 and 29 with IBD, respectively. The bacterium was detected in 83.8% of adults with ulcerative colitis (UC) and 86.1% of control subjects, showing no significant difference in prevalence (p = 0.64). Phenotypic, genotypic, and proteomic analyses revealed no distinct differences between strains from IBD patients and controls. Scanning Electron Microscopy (SEM) identified two morphological forms of the bacterium: long rods and coccobacilli. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) confirmed consistent protein profiles among isolates. The cytokine response of monocytes challenged with S. wadsworthensis strains from IBD patients and controls showed no significant differences. These findings suggest that S. wadsworthensis is unlikely to play a pathogenic role in IBD, but rather exists as a commensal organism in the gut microbiota. The comprehensive characterization of S. wadsworthensis provides valuable insights for future research on gut microbiome interactions and their implications for gastrointestinal health.
Mukhopadhya, I., Hansen, R., et al. A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease. PLoS One. 2011, 6(10): e27076. Distributed under Open Access license CC BY 4.0, without modification.
Exceptional Microbial Research Tool Sutterella wadsworthensis from Creative Biolabs is invaluable for gut microbiota studies. Its high-quality preparation ensures reliable results, making it superior to other commercial strains.
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Ideal for Gastrointestinal Microbiota Studies Sutterella wadsworthensis from Creative Biolabs is perfect for investigating gastrointestinal microbiota. Its well-documented genetic stability ensures high-quality data, proving essential for advanced microbiome research.
Advantageous for Metabolic Pathway Research
This strain is ideal for researching metabolic pathways in the gut microbiome. Creative Biolabs offers a superior product that delivers precise and reproducible outcomes, crucial for in-depth studies.
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