Probiotic strains, like other bacteria, can naturally possess or acquire antibiotic resistance genes. The concern arises when these resistance genes, particularly those located on mobile genetic elements, could potentially be transferred to pathogenic bacteria within the animal's gut, thereby contributing to the spread of AMR. Our service is designed to address this critical safety aspect by evaluating your probiotic strains in relevant animal models. We assess both intrinsic resistance (naturally occurring) and the potential for horizontal gene transfer (HGT) of antibiotic resistance determinants. This ensures your probiotic products are not only effective but also safe for animal and, ultimately, human consumption.
Animal Models
Tailoring the animal model (e.g., mice, rats, chickens, aquaculture species) to your specific probiotic application and target animal species. Considerations include genetic background, age, and health status.
Deliverables
Upon completion of the study, you will receive a comprehensive package, including:
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Deliverable Components
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Content Specifications
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Detailed Study Report
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A professional, publication-quality report outlining the study design, methodologies, raw data, statistical analysis, and clear interpretation of findings.
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Raw Data Files
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All raw data from sequencing, MIC determinations, and other assays.
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Bioinformatics Analysis Reports
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For sequencing data, including microbial community composition, ARG abundance, and resistome analysis.
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Interim Reports
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Provided at agreed-upon milestones for larger, longer-term studies.
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Turnaround Time
Turnaround times are dependent on the complexity and scope of the study, including the animal model chosen, the duration of in vivo administration, and the types of analyses requested. Typically, studies can range from 8-16 weeks from study initiation to final report delivery. We will provide a detailed timeline in your customized proposal.
