Comprehensive & Reliable Probiotic Anti-Cancer Efficacy Assay

Need Robust Anti-Cancer Efficacy Data for Your Probiotic Research? Creative Biolabs’ specialized CRO services provide comprehensive in vitro and in vivo assays to accelerate your preclinical development and validate the therapeutic potential of your probiotic interventions. Request a Quote

Accelerate Probiotic Anti-Cancer Research with Our Expert Assay Services

Workflow

In Vitro Assays (Cell-Based Studies)

• Cytotoxicity Assays
  
  • Investigate the direct cytotoxic impact of probiotics or their metabolic byproducts on diverse cancer cell lines.
  • Comparing cytotoxicity against normal cell lines to assess selective toxicity.
• Anti-proliferation Assays
  
  • Measuring the ability of probiotics to inhibit the growth of cancer cells.
  • Analyzing cell cycle progression to identify potential arrest points induced by probiotics.
• Apoptosis and Necrosis Assays
  
  • Determining if the anti-cancer effects involve programmed cell death or uncontrolled cell death.
• Invasion and Metastasis Assays
  
  • Evaluating the impact of probiotics on the ability of cancer cells to invade through extracellular matrix and migrate.
• Modulation of Cancer-Related Signaling Pathways
  
  • Investigating the effects of probiotics on key signaling pathways involved in cancer development and progression.
• Angiogenesis Assays
  
  • Assessing the potential of probiotics to inhibit the formation of new blood vessels that support tumor growth using in vitro angiogenesis assays.
• Immunomodulation Assays
  
  • Evaluating the impact of probiotics on immune cells and the production of cytokines and chemokines in the context of cancer.
• Analysis of Probiotic Metabolites
  
  • Identifying and quantifying metabolites produced by probiotics and assessing their direct anti-cancer effects.
• Gene Expression Analysis
  
  • Examining the changes in gene expression in cancer cells treated with probiotics to understand the underlying mechanisms of action.
• 3D Cell Culture Models (Spheroids, Organoids)
  
  • Utilizing more complex in vitro models that better mimic the tumor microenvironment to assess probiotic efficacy.

In Vivo Assays (Animal Studies)

• Efficacy Studies
  
  • Evaluating the ability of probiotics to inhibit tumor growth, reduce tumor burden, and prolong survival in preclinical animal models.
  • Administering probiotics through different routes.
• Metastasis Studies
  
  • Assessing the impact of probiotics on the development and progression of metastasis in vivo.
• Pharmacokinetic and Pharmacodynamic (PK/PD) Studies
  
  • Investigating the distribution, metabolism, and excretion of probiotics or their bioactive compounds in vivo, as well as their effects on tumor markers and the host immune system.
• Immunohistochemistry and Histopathology
  
  • Assess the effects of probiotics on tumor cell proliferation, apoptosis, angiogenesis, and immune cell infiltration.
• Analysis of Gut Microbiota Composition
  
  • Evaluating the changes in the gut microbiome of tumor-bearing animals treated with probiotics using techniques like 16S rRNA sequencing or metagenomics.
• Combination Therapy Studies
  
  • Assessing the synergistic or additive effects of probiotics in combination with conventional cancer therapies.

Additional Services

• Custom Assay Development: Tailoring assays to meet specific research questions and probiotic candidates.
• Strain Characterization: In-depth analysis of the probiotic strains being tested (e.g., identification, genomic analysis).

Deliverables

The general final deliverables of services for probiotic anti-cancer assays are comprehensive packages of information and data that address the research questions and provide a clear understanding of the probiotic's potential.

Turnaround Time

The typical timeframe for this service ranges from 4 to 8 weeks, depending on the complexity of the experimental design, the number of probiotic strains and conditions to be tested, and the specific assays required.

Applications

• Drug Discovery and Development: Screening and evaluating new probiotic candidates.
• Functional Foods and Nutraceuticals: Scientifically verify potential health claims related to cancer prevention or support.
• Academic Research: Explore the fundamental mechanisms of probiotics.
• Personalized Medicine.
• Combination Therapy Strategies: Study the auxiliary effects of probiotics.
• Understanding the Tumor Microenvironment: Explore the environmental impact of probiotics on the surrounding environment of tumors.
• Safety and Toxicity Assessment.
• Biomarker Discovery: Identify new biomarkers for cancer diagnosis or treatment.

Advantages

• Deep expertise at your fingertips.
• Access to cutting-edge tools and technologies.
• Faster timelines and efficiency.
• Objective and unbiased results.
• Flexibility and scalability.
• Reduced burden on your internal resources.
• Navigating regulatory landscapes.
• A collaborative partnership.

Creative Biolabs is your dedicated partner for advancing your research in Probiotic Anti-cancer Assays. We are committed to providing you with the highest quality services and support. For more information and to discuss your project in detail, please contact our team.

FAQs

Customer Reviews

• "The detailed apoptosis analysis provided by Creative Biolabs' Probiotic Anti-cancer Assay in our research has significantly improved our understanding of the anti-tumor effects of our probiotic candidate." J**n D**e.
• "Using Creative Biolabs' Probiotic Anti-cancer Assay, the high-throughput screening capabilities significantly facilitated our identification of the most promising probiotic strains for further development." M**k S**h.
• "Creative Biolabs' 3D cell culture assays provided a more physiologically relevant model, which has greatly improved the accuracy and reliability of our in vitro studies on probiotic anti-cancer effects." A**a R**z.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.