Lyophilization Development Services
Background Services Capabilities FAQs Resources
As a leader in novel LBP development, Creative Biolabs provides the most advanced facilities, capabilities, and expertise to accelerate the discovery, manufacturing, and clinical application of LBPs. Our standard lyophilization procedure has been widely applied to produce viable cultures in dried powder form.
Background
To be of practical use and convenience to consumers, probiotic bacteria must be formulated in a usable form often dehydrated through lyophilization (freeze-drying). Because LBPs are live organisms (bacteria or yeast), the dose and the viability of probiotic strains are important criteria for probiotic efficacy during storage. The therapeutic efficiency strongly depends on the viability of probiotic microorganisms. Freeze-drying (lyophilization) has been the mainstay in the preservation of pharmaceutical and probiotic drugs. This method can maximumly retain the viability and functional properties of LBPs during the storage and passage through the stomach. Lyophilisation is a complex science, involving the dehydration by sublimation of ice present within the molecules. Our specialist scientists are active in the field of lyophilization, with many years of practical experience. We have substantial knowledge of the challenges of operating an efficient and robust freeze-drying process and the experience to troubleshoot your problems.
Our Lyophilization Development Services
Development Services
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Development of cryoprotectant
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Development of excipient
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Optimization of the freeze-drying curve
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Other customized services.
Application Fields
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Microorganisms
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Nucleic acid
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Diagnostic reagents
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Bulk drugs
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Enzymes
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Coenzymes
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Vaccine
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Proteins
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Herbal ingredients
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Plant tissues
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Soil and sludge samples
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Others.
The Process of Lyophilization Development
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The clients provide lyophilization development requirements (confidentiality agreement can be signed as required).
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Provide samples to the laboratory for analysis and research, and establish technical plans.
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Provide quotations and confirm the order according to the development process.
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Start the project and update the progress regularly.
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Deliver development results and project reports to the clients for acceptance.
Deliverables
Upon completion of the development services, a final report will be issued.
Lyophilization Capabilities at Creative Biolabs
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First-class freeze dryers with flexible unit capability, vacuum set-points, and variable shelf temperature options.
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An optimized freeze-drying procedure with best-fit temperature, water activity, and atmosphere.
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Various cryoprotectants resulted in almost no loss of viability during freeze-drying.
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Optimum storage conditions.
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An appropriate combination was selected as carrier and storage conditions.
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Continuous optimization of the program and recipes to ensure a greater product yield and efficacy.
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Real-time record/analyze data, as well as operate/remotely monitor the lyophilization cycle.
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Customer-tailored material and lyophilization process compatible with the specific probiotic.
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Subsequent evaluation of the changes (stability and viability) in the probiotic efficacy during lyophilization.
Frequently Asked Questions
What is lyophilization?
Lyophilization involves creating a stable preparation of a substance by freezing it and then dehydrating the frozen product under a high vacuum. Under controlled temperature and pressure, water sublimes directly from the solid state into vapor, bypassing the liquid phase 1.
Why is lyophilization important?
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Stability: Lyophilization preserves the stability of sensitive compounds, such as microorganisms, proteins, enzymes, and vaccines.
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Long Shelf Life: It extends the shelf life of pharmaceuticals by preventing degradation.
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Transport and Storage: Lyophilized products are easier to transport and store.
Resources
Lyophilization stabilizes the product, concentrates large quantities down to a very small volume, increases its potency, and produces sizable batches, as well as makes it very easy to transport and store. As a leader in LBP discovery solutions, Creative Biolabs provides full lyophilization services spanning many organisms, industries, and production volumes. Our lyophilization can maximumly retain the viability and functional properties and is relatively low cost. If you are interested in our services, please feel free to contact us.
For Research Use Only. Not intended for use in
food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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