Expert Microbial Isolation & Screening Service: Accelerate Your Discovery

Services Case Studies Applications Advantages FAQs

Creative Biolabs provides a focused suite of Microbial Isolation and Screening Services. We understand that your research demands a solid foundation of pure microbial cultures and robust screening results. Our expertise lies in carefully teasing apart and evaluating microbial communities, delivering the high-caliber isolates and data sets necessary for you to push the boundaries of your field and accelerate your development pipeline. Through both conventional and cutting-edge microbial investigation methods, we equip you to effectively pursue your scientific objectives. Request a quote

Microbial Isolation & Screening CRO Services

Workflow

Fig.1. The colony on the plate. (Creative Biolabs Original)

Service Details

Microbial Isolation

  • Sample Processing and Preparation
    • Samples Types
Categories Sample Types
Environmental Samples
  • Soil: Different types of soil (agricultural, forest, contaminated).
  • Water
  • Surfaces: Swabs or contact plates from various surfaces (equipment, medical devices, food processing areas).
  • Sediments: Samples from the bottom of aquatic environments.
  • Extreme Environments
Humans or Animals
  • Bodily Fluids: Urine, cerebrospinal fluid (CSF), sputum, skin.
  • Stool: Human or animal stool samples.
  • Skin microbiological sample.
  • Oral microbiological sample.
Food and Agricultural Samples
  • Food Products
  • Food Ingredients
  • Animal Feed
  • Plant Samples
  • Agricultural Soil
Industrial and Biotechnology Samples
  • Bioreactors: Samples from fermentation processes.
  • Industrial Water Systems
  • Pharmaceutical Products: To ensure sterility and identify any contaminants.
  • Cosmetics and Personal Care Products: To assess microbial contamination.
  • Culturing Techniques
    • Solid Media Plating
    • Liquid Media Enrichment: Using selective liquid media to promote the growth of specific types of microorganisms while inhibiting others.
  • Pure Culture Isolation
    • Subculturing: Once isolated colonies are obtained on solid media, a single colony is aseptically transferred to a fresh sterile medium (either solid or liquid) to establish a pure culture.
    • Anaerobic/Microaerophilic Isolation: Utilizing specialized techniques and media to isolate microorganisms that grow in the absence or reduced presence of oxygen.

Microbial Screening

  • Phenotypic Screening
    • Morphological Characterization: Examining colony morphology and cellular morphology using microscopy and staining techniques (e.g., Gram staining).
    • Biochemical Characterization: Performing various biochemical tests to determine the metabolic capabilities of the isolates.
    • Growth Requirements: Determining optimal growth conditions such as temperature, pH, and nutrient requirements.
    • Antibiotic Susceptibility Testing: Assessing the resistance or susceptibility of bacterial isolates to a panel of antibiotics.
    • Biofilm Formation Assays: Evaluating the ability of microorganisms to form biofilms.
  • Activity-Based Screening
    • Antimicrobial Screening: Assessing the ability of microbial isolates to produce antimicrobial compounds against target pathogens (bacteria, fungi, viruses).
    • Enzyme Screening: Screening for the production of specific enzymes with potential industrial applications.
    • Bioremediation Potential Screening: Evaluating the ability of isolates to degrade pollutants.
    • Plant Growth Promotion Screening: Assessing the potential of isolates to enhance plant growth through mechanisms like nitrogen fixation, phosphate solubilization, or production of plant hormones.
    • Biosensor Development Screening: Identifying microorganisms with specific responses to target analytes for biosensor applications.
  • High-Throughput Screening (HTS)
  • Molecular Screening
    • DNA Sequencing: Determining the nucleotide sequence of specific genes or the entire genome.
    • Genotyping: Restriction fragment length polymorphism (RFLP) or repetitive element PCR to differentiate microbial strains.

Optional/Additional Services

  • Microbial Identification: Advanced identification of isolates using phenotypic and/or genotypic methods (e.g., MALDI-TOF mass spectrometry, 16S rRNA gene sequencing).
  • Strain Preservation: Long-term storage of isolated strains using methods like cryopreservation or lyophilization.
  • Custom Assay Development: Developing novel screening assays tailored to specific client requirements.
  • Scale-up and Optimization Studies: Further investigation and optimization of the activity of promising isolates.

Data Analysis and Reporting

We thoroughly analyze screening data and identification results to provide a comprehensive report.

Deliverables

Deliverable Components Content Specifications
Pure Microbial Cultures
  • Cryopreserved stocks
  • Lyophilized cultures (Freeze-Dried)
Comprehensive Report
  • Executive summary
  • Methodology: A detailed description of all the procedures and techniques used for sample processing, isolation, culturing, and screening.
  • Results
Raw Data
  • Images of plates, gels, and microscopy.
  • Spectrophotometer readings.
  • Sequencing files (e.g., FASTA or FASTQ formats).
  • Spreadsheets or databases containing the collected measurements.
Optional Deliverables
  • Microbial Identification Reports
  • Phylogenetic Trees

Turnaround Time

Given the variability, it's difficult to provide a precise timeframe. However, here are some general ranges:

  • Small-scale projects with basic isolation and a few simple screening assays: 4-8 weeks.
  • Projects involving isolation of specific or slow-growing microorganisms and/or more complex screening assays: 2-6 months or longer.
  • High-throughput screening projects: 3-9 months or longer, depending on the library size and the complexity of the assays.

Fig.2 Workflow of microbial identification. (Creative Biolabs Authorized)

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Case Studies

Case 1: Identified several novel bacterial strains

University Research Lab

Through our Microbial Isolation and Screening Services, a university research lab successfully identified several novel bacterial strains with potential applications in bioremediation within 10 weeks.

Case 2: Identification of novel antimicrobial compounds

Pharmaceutical Company

Our engagement directly contributed to a pharmaceutical partner's expedited drug discovery efforts. By enabling previously inaccessible marine bacteria, we facilitated the successful completion of their initial screening phase within a remarkable 12 weeks.

Applications

Pharmaceutical and Biotechnology Industries

  • Antimicrobial Discovery
  • Enzyme Discovery
  • Biologics Development
  • Microbiome Research

Food and Beverage Industry

  • Food Safety and Quality
  • Development of Starter Cultures
  • Biopreservation

Agriculture and Environmental Biotechnology

  • Plant Growth Promotion
  • Biofertilizers
  • Biopesticides

Cosmetics and Personal Care Products

  • Preservation
  • Development of Bioactive Ingredients
  • Microbiome-Based Cosmetics

Research and Academia

  • Microbial Ecology Studies: Isolating and characterizing microorganisms from diverse environments to understand microbial community structure and function.

Advantages

  • Comprehensive Approach
  • Customized Solutions
  • Expert Team
  • State-of-the-art technology
  • High-Quality Data
  • Fast Turnaround Time
  • Competitive Pricing

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FAQs

What types of samples can be used for microbial isolation?

We can handle many types of samples, see sample types above, if you do not find your sample type, please contact us to confirm.

How do you ensure the accuracy of microbial identification?

With our experienced scientists, advanced technology platforms, and excellent service cases, we have enough confidence to guarantee high-quality delivery standards.

Can you isolate microorganisms that are difficult to culture?

We, as scientific investigators, utilize innovative culture-independent strategies. Techniques like dilution-to-extinction and single-cell isolation allow us to access and isolate those fastidious microorganisms that defy conventional cultivation. If you're seeking to explore this unculturable frontier, reach out to discover how we can assist your research.

What kind of data will I receive from the screening process?

Refer to the deliverables above. For personalized delivery, please contact us.

How long does the process take?

Typically spans 4 to 12 weeks. This duration is inherently linked to the intricacies of your samples and the overall scope of your investigation.

Customer Reviews

  • "Using Creative Biolabs' Microbial Isolation and Screening Service in our metagenomics research has significantly improved our ability to identify novel microbial candidates for enzyme production." - Dr. A***n, Biotechnology Company.
  • "The comprehensive data analysis and reporting provided by Creative Biolabs significantly facilitated the interpretation of our screening results, enabling us to prioritize the most promising microbial isolates for further study." - Dr. C***s, Agricultural Research Institute.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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