Bifidobacterium longum is a Gram-positive, catalase-negative, rod-shaped bacterium. It is a microaerotolerant anaerobe and considered to be one of the earliest colonizers of the gastrointestinal tract of infants.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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LBGF-0722-GF65 |
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Product Information | |
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Product Overview | Bifidobacterium longum is a Gram-positive, catalase-negative, rod-shaped bacterium. It is a microaerotolerant anaerobe and considered to be one of the earliest colonizers of the gastrointestinal tract of infants. |
Target | Bifidobacterium |
Genus | Bifidobacterium |
Application | Study and research |
Culture Medium | BBL |
Culture Conditions | 37°C; Anaerobic |
Risk Group | 1 |
Product Format | Freeze-dried |
Packaging | Ampoule tube |
Storage | -80°C |
Shelf Life | 6 years |
Target Introduction | |
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Introduction | Bifidobacterium is Gram-positive, heterofermentative, anaerobic bacteria with a distinctive bifid; i.e. Y shape after which they are named. They are originally isolated from the faeces of breast-fed infants, members of the genus Bifidobacterium are commonly found in the GI tract of mammals. In humans, Bifidobacterium resides within the GI tract, from birth to old age. Disturbances in the microbiota are linked to an ever-growing number of immune-linked disease states including IBD, atopic allergy, arthritis, and obesity. Therefore, there is a significant interest in treating these diseases through microbial or "probiotic" supplementation of patients, including Bifidobacterium. Data from mouse models and clinical trials indicate that Bifidobacterium may have beneficial effects for treating and preventing immune-linked diseases, including gut-associated and systemic conditions. Bifidobacterium have been commercially exploited as probiotic agents due to their associated health benefits and GRAS. |
Alternative Names | Bifidobacterium longum |
Bifidobacterium longum is primarily used in research to explore its probiotic benefits, particularly in enhancing gut health, modulating the immune system, and preventing gastrointestinal disorders. Researchers also study its potential role in mental health through the gut-brain axis.
Bifidobacterium longum is distinguished by its robust ability to survive in the gastrointestinal tract, its high adhesion to intestinal cells, and its unique metabolic profile. These characteristics allow it to effectively colonize the gut and confer health benefits more efficiently than some other Bifidobacterium species.
The genomic features of Bifidobacterium longum include genes involved in carbohydrate metabolism, stress response, and production of antimicrobial substances. These genetic attributes enable the strain to thrive in the gut environment, inhibit pathogens, and support the host's health.
Bifidobacterium longum interacts with the host's immune system by modulating immune cell activity, enhancing the production of anti-inflammatory cytokines, and promoting the integrity of the gut barrier. These interactions help boost the body's defense mechanisms and maintain immune homeostasis.
Studies to evaluate the impact of Bifidobacterium longum on metabolic health include clinical trials assessing its effects on metabolic syndrome, obesity, and type 2 diabetes. Researchers also use in vitro assays and animal models to investigate its role in regulating lipid metabolism and glucose homeostasis.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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