Akkermansia muciniphila, an abundant resident of the intestinal tract, can use mucin as its sole carbon, nitrogen, and energy source. As it is the only member of Verrucomicrobia; phylum in the gut of mammals and easy to detect using its 16S rRNA gene sequence, a large number of reports indicated the variation of the genus Akkermansia in gut and associated these changes with host health and disease. Akkermansia muciniphila is an oval-shaped, non-motile, strictly anaerobic Gram-negative strain. Via mucin fermentation, it releases free sulfate and produces acetate and propionate in the gut. Akkermansia muciniphila, one of the major bacterial species in the human intestinal microbiota; 0.5%-5% of total bacteria, is an important gut symbiont for the maintenance of metabolic homeostasis and is currently recommended as a new probiotic to cope with obesity, diabetes, and liver diseases in clinics. Several studies provided evidence that Akkermansia muciniphila plays an important role in the metabolic regulation of the host. Both living and pasteurized Akkermansia muciniphila administration resulted in a reduced body and fat mass gain, declined serum triglyceride and fasting glucose levels and an enhanced insulin sensitivity in mice.