Reliable Probiotic Anti-Obesity Activity Assay Service to Advance Your Microbiome Therapeutic

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Looking to speed up your search for probiotics that fight obesity? Tired of slow progress and struggling to find the right bugs and figure out how they work? Creative Biolabs' Probiotic Anti-Obesity Assays can help you move things along faster. We use smart lab tests and animal studies to get you solid info and point you to the probiotics that show potential. Request a Quote

In Vitro & In Vivo Probiotic Anti-Obesity Activity Assays - Your CRO Solutions

Workflow

Fig.1 Workflow of assay. (Creative Biolabs Original)

In Vitro Assays

Evaluate the impact of probiotics or their components on the cellular and biochemical processes related to obesity.

  • Assessment of Lipid Metabolism
    • Inhibition of Lipase Activity.
    • Adipocyte Differentiation Assays.
    • Lipogenesis and Lipolysis Gene Expression: Analyzing the expression levels of genes treated with probiotics.
    • Quantification of Intracellular Triglycerides.
    • Fatty Acid Binding Assays: Assessing the capacity of probiotics to bind to fatty acids in vitro.
  • Evaluation of Gut Microbiota Modulation
  • Assessment of Gut Barrier Function
  • Evaluation of Anti-inflammatory and Other Metabolic Effects

In Vivo Assays (Animal Models)

Typically rodents (mice or rats) are fed a high-fat diet, to evaluate the anti-obesity effects of probiotics in a complex biological system.

  • Body Weight and Fat Mass Measurement
    • Regular monitoring of body weight gain.
    • Measurement of fat mass at the end of the study.
  • Metabolic Parameters Assessment
    • Food Intake and Energy Expenditure.
    • Glucose Tolerance Tests (GTT) and Insulin Tolerance Tests (ITT).
    • Lipid Profile Analysis.
    • Liver Function Tests.
  • Gut Microbiota Analysis
  • Inflammatory Markers and Adipokine Levels
    • Measuring circulating levels of pro-inflammatory cytokines and anti-inflammatory cytokines.
    • Assessing the levels of adipokines.
  • Histological Analysis
    • Examining tissue samples under a microscope to assess adipocyte size, inflammation, and other morphological changes.
  • Fecal Metabolite Analysis
    • Analyzing the composition of fecal metabolites, including SCFAs.

Additional Services

Deliverables

Deliverable Components Content Specifications
Comprehensive Report
  • Detailed study reports with raw and processed data.
  • Data visualizations (graphs, charts).
  • A summary of key findings and conclusions.

Turnaround Time

The typical timeframe for this service ranges from 8 to 16 weeks, depending on the specific assays required, the number of probiotic strains being evaluated, and the complexity of the in vivo studies.

Fig.2. Cell-level analysis of probiotics. (Creative Biolabs Authorized)

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Applications

Research and Development (R&D)

  • Screening and Selection of Novel Probiotic Strains.
  • Elucidating Mechanisms of Action.
  • Understanding Strain-Specific Effects.
  • Optimizing Dosage and Delivery Methods.
  • Preclinical Evaluation.

Product Development in the Food and Nutraceutical Industries

  • Development of Functional Foods and Beverages.
  • Formulation of Dietary Supplements and Nutraceuticals.
  • Quality Control and Efficacy Testing.
  • Claim Substantiation.

Pharmaceutical Industry

  • Development of Probiotic-Based Therapeutics.
  • Personalized Medicine Approaches.

Academic Research and Scientific Advancement

  • Identifying Novel Therapeutic Targets
  • Developing New Assay Methodologies.

Advantages

  • Comprehensive Approach.
  • Customized Study Design.
  • Experienced Team.
  • High-Quality Data.
  • Fast Turnaround Times.
  • Published Data: Our methods adhere to industry standards, ensuring data integrity.

Experience our advantages - Contact us today.

Creative Biolabs is committed to providing cutting-edge solutions for your probiotic research needs. Our probiotic anti-obesity testing service provides a comprehensive method to evaluate the potential of probiotic strains in controlling obesity, and can also flexibly customize your solutions at any stage of the project. Please feel free to contact us for more details.

FAQs

What exactly is a probiotic anti-obesity activity assay?

This could involve seeing if they can reduce fat accumulation, improve metabolism, mess with appetite signals, or even change the gut microbiome in a way that's beneficial for weight management.

What kind of probiotic strains can you test?

Pretty much any strain you're interested in! Whether it's a well-known Lactobacillus or Bifidobacterium species or something a bit more unusual you've isolated, we can work with it.

What kind of 'activities' do you measure?

This depends on what you're looking for, but some common things we assess are

  • Lipase inhibition: Seeing if the probiotics can block enzymes that digest fat.
  • Cholesterol reduction: Checking if they can lower cholesterol levels.
  • Adipocyte differentiation: Looking at whether they can inhibit the formation of fat cells.
  • Gut microbiota modulation: Analyzing changes in the gut bacteria composition after probiotic treatment.
  • Production of short-chain fatty acids (SCFAs).
  • Effects on inflammatory markers.

We can tailor the assays to fit your specific research goals.

What kind of samples do I need to send you?

Usually, we'll need a pure culture of your probiotic strain.

How much does this kind of testing cost?

The cost depends on the number and complexity of the assays you need.

Customer Reviews

  • "The comprehensive in vitro screening provided by Creative Biolabs significantly streamlined our strain selection process. The data was clear, and the turnaround time was impressive." - J**n Kim.
  • "Using Creative Biolabs' in vivo studies, we were able to demonstrate the efficacy of our probiotic candidate in a relevant animal model. This data was crucial for our regulatory submission." - M**a Silva.
  • "Creative Biolabs' detailed mechanism of action studies provided valuable insights into how our probiotic strain exerts its anti-obesity effects. This information will guide our future product development efforts." - D**g Patel.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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