Live Biotherapeutics Drug Discovery Service for Acne Vulgaris
Creative Biolabs is a laboratory in the CRO and live biotherapeutics field, helping to accelerate drug development through next-generation probiotics characterization services. Our service expertise lies in in-depth communication with customers, can quickly understand the specific needs of customers, and according to these needs provide flexible customized services.
Overview
Acne is characterized by sebum overproduction, hyperkeratosis of hair follicles, and increased release of inflammation-mediated chemicals. In the treatment of acne, one of the prevailing tenets has revolved around the eradication of a bacterium known as Propionibacterium acnes (P. acnes). The concept of bacterial antagonism between Cutibacterium acnes and S. epidermidis by fermentation can be used to develop topical probiotics for the treatment of acne and other skin diseases. Some skin commensal bacteria can produce anti-inflammatory and antimicrobial metabolites under conditions that mimic the follicular environment. Reduced expression of genes associated with the release of inflammatory cytokines, suppression of pathogenic CD8 T cells, and activation of regulatory T cells could serve as a potential benefit of systemic probiotics to reduce acne inflammation.
Microbiome-Based Therapeutic Approaches to Acne
Oral probiotics can modulate inflammatory cytokine release in the skin, and the specific reductions in interleukin-1α (IL-1α) that have been observed under some experimental conditions must have potential benefits in acne. P. acnes growth is inhibited by certain bacteria-secreted substances, such as antimicrobial peptides and organic acids from various bacterial strains. The in vitro inhibition of P. acnes by human-derived Lactobacillus reuteri strains was attributed to its organic acid production. Streptococcus salivarius is an important oral microorganism in healthy humans. It secretes bacteriocin-like inhibitory substances (BLIS-like substances), which can inhibit the growth of P. acnes. This so-called bacterial interference is believed to prevent the colonization of other potentially pathogenic strains by competitive inhibition of binding sites. Probiotics also reduce sebum production, which can reduce follicle colonization by P. acnes and associated inflammation.
Table 1. Probiotics and acne.
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Key Microbes Involved
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Potentially Beneficial Microorganisms
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Main Mechanism of Action
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Experimental Model
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Cutibacterium acnes
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Staphylococcus epidermidis
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Fermentation of glycerol.
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In vitro
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Streptococcus salivarius
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Production of bacteriocin-like inhibitory substance.
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In vitro
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Lactococcus sp. HY449
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Release of bacteriocin.
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In vitro
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Streptococcus thermophiles
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Increase in ceramide production, and secondary antimicrobial activity.
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In vitro, In vivo
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Lactobacillus paracasei
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Suppression of substance P-induced inflammation.
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Ex vivo
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Enterococcus faecalis
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Production of enterocins.
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In vivo
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Lactobacillus plantarum
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Production of antimicrobial peptides.
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In vivo
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Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Similar Acne Vulgaris Research
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Research Article
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Available Services
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Characterization of Weissella viridescens UCO-SMC3 as a potential probiotic for the skin: its beneficial role in the pathogenesis of Acne Vulgaris.1
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Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis.2
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After years of practice, we know that many drug developments are complex. At Creative Biolabs, you can rely on our team of experts focused on enabling you to understand and use the results. Our collaborations with many pharmaceutical companies and academic research institutions provide us with the opportunity to demonstrate our technical expertise in this field. If you are interested in our live biotherapeutics services and products, please contact us for more details.
References
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Espinoza-Monje, Marcela, et al. "Characterization of Weissella viridescens UCO-SMC3 as a potential probiotic for the skin: its beneficial role in the pathogenesis of acne vulgaris." Microorganisms 9.7 (2021): 1486.
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Kang, Mi-Sun, et al. "Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis." The Journal of Microbiology 50 (2012): 137-142.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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