Live Biotherapeutics Drug Discovery Service for Photoaging and Skin Aging
Creative Biolabs is a contract research service biology company for preclinical research. We are comprised of an expert team of dedicated scientists who have decades of experience in the field of probiotics, microbiology, and live biotherapeutics.
Overview
Skin aging can be divided into photo-aging and chronological aging. Skin photoaging is mainly caused by ultraviolet (UV) radiation, including dry skin, irregular pigmentation, coarse wrinkles, and loss of skin elasticity. It is the most important factor in causing skin aging damage.
Molecular Mechanism of Skin Aging
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Oxidative stress
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DNA damage and gene mutation
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Shortening of the telomere
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The role of microRNA
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Accumulation of advanced glycation end products (AGEs)
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Aging due to inflammation
Probiotics for Photoaging and Skin Aging
There is increasing evidence that probiotics are also able to modulate protective mechanisms in the skin. Gut microbiota is a major regulator of the gut-skin axis. Oral probiotics may protect against UV damage and alleviate inflammatory skin diseases by regulating immune-related signaling pathways. Oral and topical probiotics may become an excellent potential treatment option for skin photoaging, which can effectively protect the skin from UV damage.
Oral administration of Bifidobacterium breve B-3 can ameliorate chronic UV-induced skin photoaging in mice. B. breve B-3 can significantly reduce the transepidermal water loss, thicken the epidermis, inhibit the damage of skin-tight junction structure and basement membrane, and reduce the production of IL-1β in the skin.
Tyndalized Lactobacillus acidophilus can significantly enhance the repair ability of photoaging skin. Mice injected with tyndalized Lactobacillus acidophilus showed a significant reduction in wrinkle formation and transepidermal water loss, as well as an increase in skin moisture.
Fig.1 The role of probiotics against skin photoaging through multiple pathways.1
Based on current research, it is necessary to further explore the role of probiotics in skin photoaging from the aspects of types, usage methods, usage conditions, and molecular mechanisms of photoaging resistance, and develop more novel and effective microecological strategies to protect skin under ultraviolet radiation and delay photoaging.
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Types/Similar Photoaging and Skin Aging Research
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Research Article
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Available Services
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Heat-Killed Lacticaseibacillus paracasei ameliorated UVB-induced oxidative damage and photoaging.2
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Latilactobacillus sakei Wikim0066 protects skin on UVB-Irradiated in vitro and in vivo model.3
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Nicotinamide mononucleotide combined with Lactobacillus fermentum TKSN041 reduces the photoaging damage in murine skin by activating AMPK signaling pathway.4
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Creative Biolabs is here to help make scientific research simple and affordable. Our goal is to provide researchers worldwide with high-quality research products and customized solutions at affordable prices to meet your research needs and become a truly valuable partner in the field of life science research and drug discovery. We believe that we will only be successful when we offer the best products and services for your unique research needs. If you are interested in our services and products related to next-generation probiotics and live biotherapeutics, please feel free to contact us for more details.
References
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Teng, Yan, et al. "The Role of Probiotics in Skin Photoaging and Related Mechanisms: A Review." Clinical, Cosmetic and Investigational Dermatology (2022): 2455-2464.
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Xu, Jing, et al. "Heat-Killed Lacticaseibacillus paracasei Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms." Antioxidants 11.10 (2022): 1875.
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Park, Jeong-Yong, et al. "Latilactobacillus sakei Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model." Nutrients 15.3 (2023): 726.
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Zhou, Xianrong, et al. "Nicotinamide mononucleotide combined with lactobacillus fermentum TKSN041 reduces the photoaging damage in murine skin by activating AMPK signaling pathway." Frontiers in Pharmacology 12 (2021): 643089.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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