Live Biotherapeutics Drug Discovery Services for Netherton Syndrome

Creative Biolabs has a discovery-stage platform focused on the identification and development of next-generation probiotics (NGPs). Our excellent experts have engaged in the research of the skin microbiome and exploring the products derived from S. epidermidis (SE) for several years. We are pleased to offer a variety of solutions to develop NGPs for Netherton Syndrome treatment.

Introduction of Netherton Syndrome

Netherton SyndromeNetherton syndrome is a rare autosomal recessive genodermatosis that affects the skin, hair, and immune system. It is estimated that the incidence of Netherton syndrome is 1 in 200,000 infants. Symptoms of this disease include excessively dry scaly skin, darkened and thickened skin, red skin, and fine scales on the skin, bamboo hair, eczema, asthma, and malabsorption. Infants with Netherton syndrome may be born prematurely and present a tight, clear sheath covering their skin called a collodion membrane. Babies with this disease tend to grow slowly and have poor weight gain. Netherton syndrome is caused by the SPINK5 gene mutation located on the long arm (q) of chromosome 5 (5q32). There is currently no accepted treatment for Netherton syndrome. In general, the treatment needs to be tailored according to the patient's specific symptoms. Occasionally, some therapies such as steroids and retinoids may have adverse effects on babies.

Potential of Probiotic Treatment for Netherton Syndrome

Netherton SyndromeTwo common Staphylococcal bacteria, S. aureus, and S. epidermidis have been indicated a role in the pathology and treatment of Netherton syndrome. S. aureus is a pathogenic bacterium that causes skin inflammation and barrier damage, involved in the pathological process of some skin diseases including Netherton syndrome. While S. epidermidis is commonly found on healthy human skin and has been reported to promote wound repair, skin immunity, and suppress pathogen infections. However, S. epidermidis has pathogenic effects in some cases of Netherton syndrome.

Netherton SyndromeIn a Russian study, probiotic bacterium lysate L. rhamnosus GG or L. reuteri or B. longum have been shown to improve and/or restore the barrier function of the skin. Besides, the said lysate also has an antibacterial activity for Staphylococcus infections. These results suggest the probiotic bacterium may be useful in the treatment of some skin disorders, such as psoriasis, dermatitis, diaper rash, Netherton syndrome, actinic keratosis, and dermatomycosis.

What Can We Do?

Creative Biolabs focuses on NGPs for skin disease treatment and daily skincare. It is well known that some microorganisms, especially Staphylococcus, are rich in human skin and play an essential role in maintaining human health and skin appearance. We can leverage our extensive knowledge of NGPs to help you develop novel NGPs for the treatment of Netherton syndrome. Our services include but not limited to:

If you are looking for a company to help you discover effective NGPs for Netherton Syndrome treatment, please contact us to discuss your project.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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