Recently, probiotics appear to be potential anticancer agents that can be used in the prevention and treatment of cervical cancer. Equipped with world-leading technology platforms and professional scientific staff in the development of next-generation probiotics (NGPs), Creative Biolabs has accumulated rich experience in NGP strain identification, genomic analysis, and test your NGPs for stability along the way. We support probiotic identification for single strains and blends. Our scientists are committed to providing overall solutions for probiotic drug development to facilitate our clients' research in the prevention and treatment of cervical cancer.
Cervical cancer is the third most common cancer and the fourth leading cause of cancer-related deaths among women worldwide. Epidemiological investigations have shown that the number of new cases of cervical cancer per year is ~485,000, with 236,000 deaths occurring per year globally. There are no obvious symptoms and signs at the early stages in patients with cervical cancer. Therefore, the disease tends to be easily ignored. Over the past decade, cervical cytologic screening has generally been used to detect cervical cancer and premalignant lesions. Early diagnosis and appropriate treatment have reduced the risk of death.
Fig.1 Representation of how probiotics are involved in the prevention, diagnosis, and treatment of cervical cancer. (Jahanshahi. 2020)
Changes in the vaginal microecological environment lead to multiple gynecological diseases. Studies have shown that microorganisms may play an important role in the occurrence and development of cervical cancer. Probiotics are beneficial in different cancers. Some studies have been focused on the effects of the probiotic on cervical cancer. Findings have shown that probiotics have remarkable abilities which may lead to the prevention or treatment of cervical cancer including induction of apoptosis, inhibiting proliferation, reducing inflammation, and suppressing metastasis. Evidence suggests that concurrent use of probiotics with other therapeutic drugs results in an improvement in treatments. When combined with anti-infective drugs, probiotics have been shown to provide a better diagnostic method for cervical cancer patients.
Persistent infection with high-risk human papillomavirus (HR-HPV) is now believed to be a major causal factor in the development of cervical cancer. The bacteria in the vagina maintain a dynamic balance under physiological conditions, but the imbalance of vaginal flora leads to multiple gynecological diseases, including cervical cancer. Previous research has shown that the abundance of vaginal flora such as Mycoplasma genitalium, aerobic lactobacilli, Staphylococcus spp., Enterococcus spp., Escherichia coli, and Bacteriodes spp. in patients with cervical cancer is different from that in healthy controls. Lactobacillus is a group of bacteria that can act as a catalyst to produce lactic acid during the process of glycolysis. Many clinical studies have shown that a decline in the quantity and activity of Lactobacillus was involved in the initiation and progression of cervical cancer, which provides a novel insight into the use of probiotics to prevent cervical cancer.
Fig.2 Network illustrating the effects of Lactobacillus in cervical cancer. (Yang, 2018)
The diagnosis and treatment of cervical cancer have been advanced considerably in recent years, but there is still a long way to go regarding cancer prevention. Lactobacillus and its metabolites, which are efficacious and superior in clinical applications, may provide a novel insight into the prevention of cervical cancer.
Creative Biolabs has pioneered the discovery of novel NGPs and strain development. Our comprehensive services include but are not limited to NGP strain identification, characterization, scale Up & GMP Manufacturing. We will work with you at all stages from the initiation of your project to the large-scale production. Our professional technical scientists, comprehensive powerful platform, and abundant experience make us a perfect partner to help our clients' research in the prevention and treatment of cervical cancer. For more detailed information, please feel free to contact us or directly send us an inquiry.
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