Live Biotherapeutics Drug Discovery Service for Asthma
Overview
Asthma is a clinical syndrome of intermittent respiratory symptoms characterized by nonspecific bronchial hyperresponsiveness and airway inflammation caused by viral upper respiratory tract infection, environmental allergens, or other stimuli. It is a recognized disorder of immune function in the respiratory system. Dysbiosis of microbiota can aggravate lung inflammation and asthma-related symptoms. In recent years, particular attention has been paid to the potential influence of the human microbiome in the pathogenesis of asthma and its relationship to disease phenotypes. Immunomodulatory probiotics, either alone or in combination with other treatments, are increasingly being explored for the prevention of the onset of asthma. Preclinical studies have shown that altering the microbiota can modulate the overall host immune response, thereby reducing sensitization and allergic inflammation, and many studies have proposed the hypothesis that probiotics may have a protective effect on asthma.
Microbiota and Allergic Asthma
The lung and gut microbiota play important roles in the generation, regulation, and maintenance of healthy immune responses. The diversity and composition of the host microbiota are closely linked to the development of immune function and susceptibility to diseases including asthma. Human gut microbiota has a potential impact on the pathogenesis of asthma and is closely related to the disease phenotype. The protective effect of probiotics begins in the fetal period, and probiotics in the gut have an effect on respiratory allergies and can relieve symptoms. Probiotic supplementation around the time of birth may play an important strategic role in the prevention of asthma. Preclinical studies have shown that targeted gut microbiome manipulation with probiotics has preventive and therapeutic benefits for asthma. The preventive effect of Lactobacillus on RTIs may help to alleviate the acute exacerbation of asthma. Therefore, probiotic supplementation may become a new way to prevent/treat allergic diseases.
Fig.1 Effect of probiotics on allergic asthma.1
Mechanisms of Microbiota-Immune Interactions in Asthma
Probiotics provide immune protection to the host by regulating, stimulating, and modulating immune responses, and have been widely promoted for their positive effects on suppressing abnormal immune responses, such as asthma. At the same time, probiotic supplementation can alter the systemic metabolic profile, block the development of pathogenic immune responses, and reduce lung diseases. Additional SCFAs, butyrate and propionate, can induce regulatory T-cell development which may play an important role in protection against allergic and inflammatory diseases.
Our Probiotic Services for Asthma Research
Creative Biolabs is a full-service contract research organization (CRO) that also supports preclinical studies of Live Biotherapeutics drugs. Our focus is on finding customized solutions to our clients' outsourcing needs. Our experienced scientific team will manage the whole process so that the customer's research projects are more quickly and safely landed, please feel free to contact us, and we will promptly answer your questions.
References
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Huang, Jinli, et al. "Effect of probiotics on respiratory tract allergic disease and gut microbiota." Frontiers in Nutrition 9 (2022): 821900.
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Sagar, Seil, et al. "Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma." Respiratory research 15 (2014): 1-17.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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