Living biotherapeutic products (LBPs), as a kind of biological products, have broad application prospects in the prevention or treatment of metabolic diseases and pathogenic infections. The safety evaluation of LBPs needs further special consideration compared to traditional medicines, due to the peculiar biological properties and mode of action of the live microorgaisms that they contain.
With the development of analytical methods, such as the next-generation sequencing and bioinformatics platforms, many potential NGPs have been discovered or currently under intensive development.
Under healthy conditions, dynamic interactions exist between the host cells and the vast diversity of microbiota microbes to keep a balance. Once the situation of microbiota dysbiosis, lots of diseases will be developed.
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