Mycobiome–Microbiome Interaction Modeling Services
Our service section is built for antifungal R&D teams that need actionable mixed-community evidence, not broad microbiome commentary. Each module can be run as a standalone workstream or combined into a data package for candidate selection, mechanism exploration, formulation comparison, or partner-facing study planning.
Candida-Bacteria Co-Culture Model Design
We design and execute co-culture systems that pair clinically relevant Candida species with bacterial partners selected for the target niche, such as lactobacilli for vaginal models, staphylococci or corynebacteria for skin models, and anaerobic or facultative gut bacteria for intestinal programs. Model parameters can include inoculation order, strain ratio, media chemistry, oxygen exposure, pH control, surface format, and planktonic versus biofilm conditions.
The goal is to expose how bacterial context changes fungal growth, morphology, adhesion, and susceptibility, so your team can interpret antifungal activity under conditions closer to the intended biological setting.
Mycobiome Profiling and Community Baseline
We support fungal and bacterial community characterization using culture-based enumeration, targeted qPCR, sequencing-aligned profiling strategies, and strain-level tracking plans where appropriate. These baselines help determine whether a model contains the intended ecological pressure before candidate testing begins.
Mixed Community Response Testing
We measure antifungal impact across viability, biofilm biomass, metabolic activity, hyphal transition, community composition, and recovery after treatment. Readouts are selected to distinguish direct fungal inhibition from broader microbial-community remodeling.
Microbiome Impact Assessment
For candidates that may be used in microbiota-rich sites, we evaluate whether exposure suppresses beneficial bacteria, shifts fungal-bacterial balance, or leaves a community state that could favor regrowth. This is especially useful for comparing narrow antifungal activity with broader ecological disturbance.
Mechanism-Focused Interaction Mapping
When a program needs mechanistic support, we can structure assays around pH, secreted metabolites, contact dependence, biofilm matrix contribution, quorum-linked behavior, and bacterial protection or sensitization of fungal cells.
