Lactobacillus rhamnosus; 3690 has the potential to prevent and treat human diseases associated with increased intestinal permeability.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
Product Information
Product Overview
Lactobacillus rhamnosus; 3690 has the potential to prevent and treat human diseases associated with increased intestinal permeability.
Target
Lactobacillus
Genus
Lactobacillus
Strain Designation
CNCM I-3690
Application
Study and research
Culture Medium
MRS
Culture Conditions
37°C, Anaerobic
Risk Group
1
Product Format
Freeze-dried
Packaging
Ampoule tube
Storage
-80°C
Shelf Life
6 years
Target Introduction
Introduction
Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, convex, and translucent. Some species of Lactobacillus used commonly as probiotics. They are most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome; IBS, colic in infants, and many other conditions that involve the stomach and bowel.
Alternative Names
L. rhamnosus
FAQsPublished Data Customer Reviews Related Products
How should Lactobacillus rhamnosus be cultured for experimental use?
For culturing Lactobacillus rhamnosus, it is recommended to use standard anaerobic culturing techniques. The bacterium should be grown in appropriate media at 37°C under anaerobic conditions until the desired density is achieved. This ensures optimal viability and activity for experimental applications.
What are the recommended methods for administering Lactobacillus rhamnosus in animal models?
In animal studies, Lactobacillus rhamnosus can be administered orally through gavage, mixed in drinking water, or included in the diet. The dosage and duration depend on the specific research goals but generally range from 10^8 to 10^9 CFU per day.
Can Lactobacillus rhamnosus be used in studies related to stress and anxiety?
Yes, Lactobacillus rhamnosus has been shown to reduce subjective stress and anxiety levels in human trials. It helps in mitigating stress-induced gut permeability, making it useful for studies exploring the gut-brain axis and the effects of probiotics on mental health.
What are the typical assays used to evaluate the effects of Lactobacillus rhamnosus on gut barrier function?
Common assays include measuring transepithelial electrical resistance (TEER), evaluating tight junction protein expression, and conducting permeability tests using markers such as lactulose and mannitol. These assays help in assessing the probiotic's ability to enhance gut barrier integrity.
Are there any safety considerations when using Lactobacillus rhamnosus in research?
Lactobacillus rhamnosus is generally considered safe for research purposes. However, standard microbiological practices should be followed to prevent contamination and ensure the integrity of the experimental results. It is also important to validate the strain's identity and purity before use.
Stress-induced increase in salivary cortisol (a) and STAI (b) in the intention-to-treat population
The study investigates the effects of the probiotic Lactobacillus rhamnosus CNCM I-3690 on stress and intestinal permeability. Conducted on healthy students, the trial used a double-blind, placebo-controlled design to measure outcomes. Participants consumed either L. rhamnosus or a placebo for four weeks. The primary outcome measured was intestinal permeability using the lactulose-mannitol ratio (LMR), while secondary outcomes included salivary cortisol levels, State-Trait Anxiety Inventory (STAI) scores, and Perceived Stress Scores (PSS). Results showed no significant difference in LMR between the treatment and placebo groups. However, within-treatment analysis revealed that L. rhamnosus CNCM I-3690 prevented a stress-induced increase in the fractional excretion of mannitol (FEM). The probiotic significantly reduced subjective stress markers, as evidenced by lower STAI and PSS scores during stress, compared to placebo. These effects were independent of changes in intestinal permeability, suggesting that L. rhamnosus CNCM I-3690 may have anxiolytic properties beneficial for managing stress.
Wauters, Lucas, et al. "Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: A randomized placebo-controlled trial." Gut Microbes 14.1 (2022): 2031695. Distributed under Open Access license CC BY 4.0, without modification.
Exceptional Gut Barrier Research Tool Lactobacillus rhamnosus has proven invaluable in gut barrier function studies, providing consistent and reliable results. The probiotic's ability to enhance tight junction proteins makes it superior to other products.
Outstanding Immune Modulation
The immune response modulation by is remarkable. Its effects on cytokine profiles are critical for our inflammation research, making Creative Biolabs' product a preferred choice.
Superior Quality and Performance
Creative Biolabs' Lactobacillus rhamnosus stands out for its high quality and consistent performance in experiments. This probiotic has significantly advanced our understanding of intestinal microbiota interactions .
Reliable Stress-Reduction Studies
This strain has shown excellent results in stress-related gut permeability studies, offering reliable data for gut-brain axis research. The quality of Creative Biolabs' product ensures dependable outcomes.
Enhanced Research Outcomes
In comparative studies, Lactobacillus rhamnosus from Creative Biolabs demonstrated superior efficacy in enhancing gut health and immune response, outperforming similar products in the market.
Click the button below to contact us or submit your feedback about this product.
