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Lactobacillus acidophilus derived Extracellular Vesicles (EVs) (CAT#: LBGF-0326-GF13)

This product consists of purified extracellular vesicles (EVs) harvested from the culture supernatant of Lactobacillus acidophilus. These vesicles are biogenic, lipid-bilayered nanostructures that play a critical role in intercellular communication, immune modulation, and host-microbe interactions. Unlike live probiotics, these EVs are non-replicating, making them a "postbiotic" component suitable for research into targeted delivery, vaccine development, and therapeutic signaling.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

SPECIFIC INQUIRY
Isolation Tech:
Product Format:
Formulation Matrix:
Modification:
Protein Characterization:
Osmolality Testing:
Microbial Sterility Testing:
Mycoplasma Test:
Endotoxin Testing:
Heavy Metals Analysis:
Transcriptomics:
Proteomics:
Metabolomics:
Lipidomics:
Microbiomics:
Membrane Proteomics:
Fluorescence Labeling:
Tracer Imaging (In Vivo Tracking):
Cargo Loading (The "Payload"):
Drug Loading Concentration Detection:
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Product Information
Product Overview This product consists of purified extracellular vesicles (EVs) harvested from the culture supernatant of Lactobacillus acidophilus. These vesicles are biogenic, lipid-bilayered nanostructures that play a critical role in intercellular communication, immune modulation, and host-microbe interactions. Unlike live probiotics, these EVs are non-replicating, making them a "postbiotic" component suitable for research into targeted delivery, vaccine development, and therapeutic signaling.
Target Lactobacillus EVs
Source Microorganism Lactobacillus acidophilus
Size Scalable Bio-Volume, from pilot-scale (mg) to industrial-scale (grams) yields based on your study phase.
Total Protein BCA Assay
Particle Concentration NTA size profiling.
Particle number varies by lot. Please refer to the attached CoA.
TEM The morphology of exosomes was observed by transmission electron microscopy.
Purity Grade Research Grade (Standard)
Lead Time 4-6 weeks (Includes cultivation, isolation, and full COA characterization).
Storage 1. Liquid Format: Store at -80°C.
2. Lyophilized Format: Store at 2°C to 8°C.
Shipping 1. Liquid: on dry ice.
2. Freeze-dried powder: with ice packs.
Stability Each custom batch includes a 6-month stability under specified conditions.
Functional Validation Services Our comprehensive validation suite assesses the bioactivity, safety, and therapeutic potential of microbial-derived EVs (exosomes) across multiple biological dimensions.
1. Cellular Dynamics & Regenerative Potential
a. Cell Proliferation Analysis
b. Cell Cycle Profiling

2. Survival & Barrier Integrity
a. Apoptosis Quantification
b. Invasion & Barrier Penetration

3. Immunomodulation & Anti-Inflammatory Activity
a. Inflammation Modulation Assay
b. Pro/Anti-Inflammatory Profiling

4. In Vivo Bioactivity & Safety Models
a. Zebrafish Screening Model
b. Murine (Mouse) Validation Model

5. Custom Functional Customization
Don't see a specific assay? We offer bespoke protocol development to match the unique properties of your specific probiotic strain.
Applications 1. Advanced Immunomodulation & Cytokine Signaling: Probiotic-derived EVs (pEVs) are potent mediators of the innate and adaptive immune systems. Unlike live probiotics, pEVs can safely penetrate the mucosal barrier to interact with dendritic cells and macrophages.
2. Gut-Brain Axis & Neurobiology: pEVs are recognized as critical long-distance messengers in the gut-brain axis.
3. Skin Barrier Integrity & Aesthetic Science: In skin research, pEVs act as "postbiotic" powerhouses.
4. Next-Gen Drug Delivery Scaffolds: Due to their natural origin, pEVs possess inherent biocompatibility and low immunogenicity, making them ideal candidates for "bio-hybrid" drug delivery systems.
Alternative Names L. acidophilus
Quality Control
Osmolality Testing Osmotic pressure molar concentration tester
Microbial Sterility Testing By cultivation method.
Mycoplasma Test qPCR method
Endotoxin Testing Endotoxin detection kit
Heavy Metals Analysis Lead, cadmium, chromium, mercury, and arsenic levels were determined using the Atomic Absorption method.
Multi-omics Analysis
Transcriptomics 1. Small RNA-Seq
2. LncRNA-Seq
Proteomics DIA technology
Metabolomics LC-MS
Lipidomics LC-MS
Microbiomics 16S rRNA sequencing
Membrane Proteomics Proximity Barcoding Assay (PBA)
Tracing Modification
Fluorescence Labeling Exosomes are typically incubated with lipophilic dyes that integrate into the lipid bilayer.
Tracer Imaging (In Vivo Tracking) 1. Cell confocal photography.
2. Zebrafish fluorescence observation.
3. In vivo imaging of small animals.
Cargo Loading (The "Payload") 1.Ultrasound (Sonication).
2. Lipid Anchoring.
3. Click Chemistry.
4. Transfection.
5. Gene Overexpression.
6. Gene Interference.
Drug Loading Concentration Detection HPLC/LC-MS

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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